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This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…

Together with researchers from over the world, the ENIGMA-Anxiety Working Group endeavors to unravel the neurobiology of anxiety disorders and related constructs.

People already diagnosed with a mental disorder before the COVID-19 pandemic did not show a disproportionate increase in symptoms afterwards. This is one result from the first systematic review of longitudinal studies following their study population from before to during the first eighteen months of…

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Autism spectrum disorders are more often diagnosed in boys than in girls. For Developmental Psychology professor Carolien Rieffe this raises the question whether autism remains undiscovered in girls and women.

On 9 November, Roosmarijn van Es defended the thesis 'The mind in the courtroom: on forensic mental health reports in judicial decision-making about guilt and sentencing in the Netherlands. The doctoral research was supervised by Jan de Keijser, Maarten Kunst and Janne van Doorn.

What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

Clinical psychology is a discipline concerned with the application of psychological science to the assessment and treatment of mental disorders.

In this project we followed children of parents with an anxiety disorder. We wanted to examine how these children develop and try to better understand why it is that some children develop fears, whilst other children do not. In this project, we mainly focus on social anxiety disorder and panic disor…

The overarching aim of this theme is to increase our understanding of the mechanisms underlying altered cognitive, affective, and social behavior in relation to mental health problems.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Brave Little Ones is a research group that investigates the potential prevention of anxiety disorders in children aged 3-6 years old who are very shy or anxious.

Can excessive worrying be reduced via stimulation of the vagus nerve?

Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations. The drug D-cycloserine may help here. These are the findings of psychologist Mirte Brom.

A study into the impact of historical socioeconomic changes on the respiratory health of past Dutch populations (ca. 470-1850 CE)

FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…

Supervisor: Indira Nederpelt

Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior

Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Members of our research team give different types of presentations and lectures.

Empathic or anxious mistakes? A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

The group Clinical Neurodevelopmental Sciences has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

Promotor: Prof.dr. J. den Hertog

An assessment approach that tailors to children’s instructional needs

From basic science to real-world interventions

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

This focus area adresses the mental well-being of people of all ages, from infants to the elderly. The emphasis lies on understanding, preventing, and treating mental health problems in a variety of contexts, such as the family, school, and work environment. We carry leading research and education programmes…

Electronic versions of our publications can be obtained by sending an e-mail to Esther van den Bos: bosejvanden@fsw.leidenuniv.nl

How do people acquire language? How can you train your brain? What is the effect of stress on an unborn child? LIBC research topics range from language processing to cognitive robotics, and from psychiatric disorders to the impact of social factors on human behaviour. Meet several main research topics…

Analysis of neuroimaging data requires multiple steps where statistics play a crucial role. The MRI methods research group develops new statistical methods that are accurate, transparent and easy to use.