The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Reasserting America in the 1970s brings together two areas of burgeoning scholarly interest.

Psychologist Bernadet Klaassens initiated a large fMRI study on the effect of drugs on brain networks in aging and Alzheimer's disease. It generated a unique data set and insight into a new method to develop drugs for patients with Alzheimer's.

Bispecific antibodies with one Fab arm binding to effector cells, such as T-cells and NK-cells, while the other Fab arm recognizing a tumor associated antigen (TAA) can be used to redirect these effector cells for tumor specific killing. Using bispecific antibodies to treat hematological cancers is…

In this thesis, the focus lies on studying glucocorticoid receptor dynamics in living cells with the aim of understanding how this transcription factor finds its DNA target sites to regulate transcription.

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

PhD defence

2020 was an eventful year. You can see that in our photos: one and a half metres distance, an empty university, attending ceremonies online and working from home. The image editors have selected the twelve most eye-catching photos of the past year..

Promotor: B. van de Water

LUMC researcher Marius Staring will receive a $ 200,000 grant from the Chan Zuckerberg Initiative to improve the accessibility, interoperability and efficiency of the Elastix imaging software. This will give the popular 2003 software package a much-needed new impulse.

How do bacteria sense and adapt to their environment? Ariane Briegel, Professor of Ultrastructural Biology, is intrigued by this question. Using new techniques, she produces three-dimensional images of bacteria that provide us with new clues about their sensory system.

Sander Blok has won the third edition of the annual LION Image Award. He created a colorful image of gold nanoparticles with a low-energy electron microscope.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Leiden University and VU Amsterdam are developing a joint research project for a digital platform on which you can compose and share storylines with the use of images. Such interactivity will make a boring high school history lesson much more exciting and personalized. Furthermore, it will stimulate…

Mazène Hochane and Xueying Fan have won the fourth annual LION Image Award. They created a detailed colour image of a human kidney in development.

Marius Staring, Associate Professor at the LUMC has been awarded the Chan Zuckerberg Initiative funding for further development of image processing software Elastix

The following students have been part of LAPP:

This project investigates the transposition of natural historical material, knowledge and vision, between different media (collection, scientific drawing, academic texts, the visual arts and/or literature) – a transmission that happens in the borderline between the traditional, emblematic worldview…

The project '‘The Temporality of Images: Merleau-Ponty’s Visual Ontology and its Resonances with Chinese Landscape Painting.’, in the most concise terms, explores ontological questions through the lens of images, drawing on phenomenology, iconology, art history, and comparative philosophy.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

Illegal images spread fast via social media. That became painfully clear last week following incidents involving teenagers in Dutch towns. Bart Schermer, Professor of Law and Digital Technologies, spoke to NRC newspaper about the role and responsibility of social media platforms.

Political parties are calling for a ban on sharing images of victims. Bart Schermer, Professor of Privacy & Cybercrime, spoke about this with Rijnmond: ‘Criminal law is too often used to solve societal problems.’

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Tech company Eyeball collects images and data on young amateur football players on a large scale. But is this allowed? Bart Custers, Professor of Law and Data Science, and Gerrit-Jan Zwenne, Professor of Law and Digital Technologies, comment on the issue in ‘NRC’ newspaper.

In this thesis, we have studied cell images from two types of cells, including pollen grains and the immune cells, neutrophils. These images are captured using a bright field microscope and a confocal microscope.

The Leiden Centre of Data Science and the Leiden Institute of Advanced Computer Science are part of a consortium that will carry out research on making illustrated and handwritten archives digitally accessible. The project is funded by NWO.

Noah Millman defended his thesis on 26 May 2015

Marietje Beemsterboer defended her thesis on 12 June 2018 (in Dutch)

Promotor: K.J. Batenburg

The Microscopy Unit houses, maintains and coordinates most of the microscopy equipment of the IBL. The available equipment ranges from conventional light and fluorescence microscopes, to confocal laser scanning and electron microscopes. In addition, infrastructure is available for histology, including…

On 14 September 2021, Bram van der Sar defended his thesis 'Fiscale geheimhoudingsplicht: art. 67 AWR ontrafeld'. The doctoral research was supervised by Prof. J.P. Boer and Prof. A.O. Lubbers.

Promotores: R. Tijdeman, K.J. Batenburg

Research using the ALMA telescope by scientists including Leiden's John Tobin and Steven Bos has produced the first images of the water snow line within a protoplanetary disc. Publication in Nature on 14 July.

The aim of this thesis was to develop and evaluate a Ecological Professional Development Model to support preservice biology teachers to direct their own subject-specific ecological professional development route.

On 18 November 2021, Anneke Keulemans defended the thesis 'Het Unierechtelijke verdedigingsbeginsel'. The doctoral research was supervised by Prof. J.P. Boer and Prof. A.O. Lubbers.

Researchers from the University of Oxford’s Bodleian Libraries and from universities in the Netherlands have used high-tech imaging to uncover the details of a rare Mexican codex dating from before the colonisation of America.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

Queen Juliana was not, as is often claimed, a monarch with an unstable character who was completely under the influence of spiritual healer Greet Hofmans. Furthermore, her religious circle of friends was not a sect with a political agenda. That is what Han van Bree concludes on the basis of a new archival…

PhD defence

Over a seven year period an international team of scientists has mapped more than a quarter of the northern sky using the Low Frequency Array (LOFAR), a pan-European radio telescope. From Leiden, Astronomer Timothy Shimwell and Huub Röttgering, among others, are involved. It reveals an astonishingly…

Associates of Leiden University Center for Intercultural Philosophy

Below you will find an overview of the publications of The Leiden Advocacy Project on Plastic.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.