Maria discusses her case studies with a broader public

The Centro de Estudos Internacionais at Instituto Universitário de Lisboa (ISCTE-IUL) will host the

On Thursday 23 May, a jointly organized Lunch Seminar between the Leiden Research Lunch and the research program Interaction Between Legal Systems takes place. In this special seminar we have the honour of receiving Maria Weimer from the University of Amsterdam, who will present her new book on

Maria de Jong-de Kruijf was awarded a doctorate degree on 7 March for her research on children in secure residential youth care. The Dutch website for legal professionals, Mr. Online, interviewed her for their ‘lawyer of the week’ column.

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

Prisoners who have little or no contact with the outside world are more prone to reoffend. What makes visits so important?

The centre of our Galaxy is so dark and dense that it is almost impossible to observe what is inside. By catching the rare hypervelocity stars that are ejected from it, Elena Maria Rossi aims to unveil the mysterious environment around the supermassive black hole inside. But she’ll also be solving another…

Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…

The monthly ILS Lunch Seminars unite the several Institutes situated within Leiden Law School. On Thursday 15 February 2018 from 12:00 hrs until 13:00 hrs in KOG B0.41, the next edition of the ILS Lunch Seminars will take place.

Of the 111 Spinoza Prizes that have been awarded since 1995, 28 have gone to researchers from Leiden University.

PhD defence

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Research in the Lars Jeuken group focusses on redox-active proteins and membranes enzymes, aiming to understand bacterial respiration at the molecular level for the development of antimicrobials and semi-artificial photo-synthetic cells.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

Control of infectious diseases poses continuous challenges for human health.

Researchers at Leiden University Medical Center (LUMC) and Radboud university medical center have been given the green light to deliberately infect volunteers with malaria in order to test a highly promising vaccine on them.

How do mycobacteria subvert the defenses of host immune cells?

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Estudio arqueológico de la primera ciudad española en la Tierra Firme de América: Santa María de la Antigua del Darién

Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.

How can efficient chemical synthesis and clinical microbiology be combined to identify new antibiotics against Clostridioides difficile infections?

This project focuses on two Mayan languages in contact: Awakateko and K’iche’. With the aim to create a database to be accessible to researchers, students, and indigenous activists interested in Mayan languages, this project will train Mayan speakers on transcription, translation, and analysis of…

Source: PLoS ONE, Volume 10, Issue 3 (2015)

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

In STAYAHEAD data-intensive approaches are being developed to ”decode the human immunome” with a focus on a global vaccine strategy. They have developed a rapid mass spectrometric test to analyse in real-time large numbers of variants of SARS-CoV-2 and the host immune response, and use these data to…

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Publishing about your research is a key aspect of your career as a researcher; the majority of research publications are written in English. When applying for research funding, too, it is very important to ensure that your application is written in clear, accessible English. Maria Sherwood-Smith, Academic…

Un)timely Crises explores how ‘crisis’—as a narrative, concept, grammar, and experience—structures time and space. This collectively written volume extends Bakhtin’s ‘chronotope’ to challenge mobilizations of crisis within neoliberal governmentality. The book explores how contemporary crises can trigger…

Antimicrobial resistance (AMR) is the phenomenon that pathogens become insensitive to the antibiotics that we use against them. A growing number of pathogens is becoming resistant, with methicillin-resistant S. aureus (MRSA) as the most famous example. But while the threat of AMR represents a slow-moving…

The Translational Immuno-Pharmacology group works on translating the efficacy of anti-infective therapy from preclinical (e.g. in vivo) to clinical, and is led by Rob van Wijk. Infectious diseases, such as tuberculosis, are in constant need of new therapies that work better, faster, and with less risk…

Uncover novel antimicrobials with prospective health benefits for sea turtles.

Among Leiden’s Firsts was Hajjah Maria Ulfah Soebadio Sastrosatomo. In 1933, she was the first Indonesian woman student to earn a law degree.

Kazimierz Twardowski (1866-1938) is the founder of the Lvov-Warsaw School with its strong tradition in logic and its scientific approach to philosophy. Twardowski’s unique way of doing philosophy, his method, is of central importance for understanding his impact as a teacher.

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

This network brings together scholars whose work explores how contemporary frameworks of crisis produce experiences of the present, rehash or disrupt established narratives of the past, and broker specific outlooks on the future. We collaborate in studying these crisis-scapes and exploring how they…

Macrophages – the front line of our immune system – protect us from infections. But in the case of the tuberculosis bacteria, this often goes wrong. The group of Annemarie Meijer from the Leiden Institute of Biology has now discovered that macrophages in zebrafish are better able to eliminate tuberculosis…

For a full overview of the publications of the Translational Immuno-Pharmacology group, visit the Google Scholar page.