Emotions play a key role in EU politics. This article examines how emotions influence the EU’s response to international crises and norm violations.

PhD defence

This catalogue is the result of the EU_CUL project (2018-2021), which explores the use of cultural heritage in Europe for fostering academic teaching and social responsibility in higher education.

Promotor: Prof.dr. W.J.G.M. Peijnenburg, Co-promotor: Dr. ing. M.G. Vijver

Voting Advice Applications represent popular election campaign tools in many countries, enabling voters to discover which party or candidate provides the best match with their political preferences. Political scientists Martin Rosema (University of Twente) and Tom Louwerse (Leiden University) examine…

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Emerging from the first wave relatively unscarred to an increase in infections. This research analyses the response from the Bulgarian government to Covid-19.

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

On 7 May 2020, Jolanda van der Vliet defended her thesis 'The International Legal Protection of Environmental Refugees. A human rights-based, security and State responsibility approach'. The doctoral research was supervised by Prof. N.J. Schrijver and Prof. J.J.C. Voorhoeve.

Despite substantial progress in understanding tuberculosis (TB), the eradication of the TB epidemic is still far from reach.

Across Europe, the need for a more dynamic governance and a better societal integration of research and innovation is increasingly appreciated. Internal drivers of change (such as the digitalization of science) and political will to better align with societal needs and concerns are bringing about aspirational…

Up to 50% of all children and adolescents growing up worldwide are exposed to at least one form of childhood adversity (CA), which is one of the strongest predictors for later-life psychopathology.

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

This article examines to what extent bureaucratic responsiveness depends upon the source, the content and the salience.

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

New and reemerging infectious diseases call for innovative and efficient control strategies of which fast vaccine design and development represent an important element.

Corneal transplantation is one of the most common human organ transplantations worldwide. Although the 1-year survival rate is as high as 90%, more than half of transplantation patients suffer various types of corneal rejection, such as epithelial rejection, chronic stromal rejection, and endothelial…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

PhD defence

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

Leiden has a long history in the treatment of blood cell cancer. Research to find better therapies never stands still. One of the potential treatments currently being worked on is a ‘living medicine’.

Treatment with special stem cells seems to be a good option for suppressing the immune system in organ transplants. Researchers are trying to learn from processes that take place in the human body during pregnancy.

How do plant defense genes get activated?

Lecture

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Vaccination via the skin or the mucosae

PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Atherosclerosis is a chronic inflammatory disease affecting millions of people world-wide.

Appropriate animal models for intradermal vaccine delivery are scarce. Given the high similarity of their skin anatomy to that of humans, minipigs may be a suitable model for dermal vaccine delivery.

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

It is often said that the true character of a person is only revealed in a crisis. In these days, the coronavirus causes concern about the true state of the multilateral system. Political scientist Gisela Hirschmann (Leiden University) is worried about the future of multilateralism.

In online games conflicts between players may arise. Novin, Bos, Stevenson and Rieffe investigated factors that may explain why some adolescents react more angrily than others in this type of situation. In their realistically designed gaming environment, the (pre-programmed) fellow player suddenly started…

Promotor: E.F. Smets Co-promotor: J. Geml

In this article Wouter Jong and Andrea Bartolucci explore the integration of scenario-based learning (SBL) into a crisis communication course to enhance students' practical skills and reflection in real-world contexts.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

In the face of threats from other groups, humans, chimpanzees, and a selection of other species get closer with their own. This research shows that even bonobos show a moderated version of this effect. This suggests that this behavior may emerged prior to the Pan-Homo split, several millions years ago.…

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.