Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

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Develop EPR instrumentation and methodology to investigate intrinsically disordered proteins (IDPs).

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

On a structural level, the properties featured by a majority of mechanical metamaterials can be ascribed to the finite number of soft internal degrees-of freedom allowing for low-energy deformations.

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

Are there any differences in gaze behavior between high and low socially anxious individuals? What factors influence the relation between social anxiety and gaze behavior?

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Advanced UHF MRI techniques provide powerful tools for studying the zebrafish brain, an emerging model in neurological research. In this work, various MRI and localized MRS methods are optimized and employed for UHF strength for studying the zebrafish brain.

This thesis describes a study from both a theoreticaL and an experimental point of view.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Our everyday life consists of all sorts of spatial processes: we find our way to work, remember where we left our keys, and are able to pick up our cup of coffee. We study how the human brain processes such spatial processes. From a clinical perspective, we are interested in how acquired brain damage…

What are the functions of the endocannabinoid system?

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How do genetic and environmental factors make us vulnerable to depression?

Promotor: M.L. van Hecke, Co-Promotor: B.P. Tighe

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

In the first part of this thesis we study the geometry of folding patterns.

The group is involved in training in areas of diagnostic skills, treatment/prevention/intervention, neuropsychological assessment, behavioral observations, clinical interviewing, knowledge of intellectual disability, autism, ADHD, psychosis and aggression.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

We investigate emergent structures and dynamics of soft materials self-assembled from microscopic constituents.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

The division of BioTherapeutics consists of the former divisions Biopharmaceutics and Drug Delivery Technology.

This study tests whether behavioural problems at a young age are related to early reading and mathematics development.

Dr. Pauline Aarten tries to find answers of the impact a road traffic accident has on the victims and surviving relatives and how we can improve their position.

From basic science to real-world interventions

The ability to count is a property not often attributed to materials, despite the abundance of memory in materials. Regardless of how a material stores information, it is often difficult to retrieve exactly ‘what’ a material remembers.

Consensus and harmony or balance and reciprocity?

The first results of the “Policing European Metropolises project” (PEMP) that associate Professor Elke Devroe and Professor P. Ponsaers launched in April 2013 are now published. Having been the referent for The Netherlands and Belgium in the Urbis project (Leonardo programme), the project focuses on…

The research connected to this topic is related to E-health.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Childhood sexual abuse is a common problem, with approximately one in five girls and one in 13 boys worldwide experiencing some form of sexual abuse before the age of 18. Despite its high prevalence, many individuals remain silent about these experiences, often delaying disclosure for years, with one…

Legitimacy is generally a term that is associated with the state. The term surfaces when there are problems with state legitimacy—when it is lacking or absent. This present volume attempts to think through the relevance of the concept of legitimacy for other political actors than the state.

This study endeavors to reconstruct Plato's theory of change and motion. The diverse perspectives of pre-Socratic philosophers regarding change and motion provide the context for Plato’s exploration of his theory.

Agricultural foods naturally vary in their detailed internal structure. To facilitate early detection of health hazards due to contamination or disease, predict maturity and minimize wastage, it is critical to take into account the internal characteristics of each individual product, as these enable…

Promotor: M.L. van Hecke

Welcome to the Social Anxiety and Specific Phobia (SASP) Research Group!

We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.

Neurobiological, cognitive and behavioural measurements of normal and abnormal child development.

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Glycosidases are essential in fundamental biological processes and are responsible for the degradation of most (oligo)saccharides, glycolipids and glycoproteins.

Toward optimal measurement and greater understanding of youth cognition in school refusal and cognitive behavioural therapy outcome

This website showcases Leiden University’s contribution to the SSH Sector Plans.

The project Advancing The European Multilingual Experience (AThEME) studied multilingualism in Europe by incorporating and combining linguistic, cognitive and sociological perspectives.

PhD defence

The more opportunities a child has to learn and develop, the stronger his or her future position in society. Leiden University investigates how the brain picks up information, and how learning processes can be influenced positively.