PhD defence

Already during their bachelor’s programme, students in Pharmaceutical Sciences are presented with challenging projects. One of these is the Bachelor Research Assignment (BOO in Dutch), which is often their first real experience with scientific research. This means a lot of responsibility and failures,…

The drug BIA 10-2474 inhibits fatty acid amide hydrolase (FAAH), a lipase that degrades a specific endocannabinoid. On the basis of this activity, BIA 10-2474 was being developed as a potential treatment for anxiety and pain. In a phase 1 trial of the drug, one subject died, and four others suffered…

Since the attack of 22 may 2017 in the Manchester Arena, we have often seen the term ‘soft target’. Jeanine de Roy van Zuijdewijn, researcher at the Institute of Security and Global Affairs, took part in a Q&A about the attack in Manchester.

eLaw is thrilled to let you know that on 29 April (17:00-19:00), we will be hosting Prof. Luciano Floridi, Prof. Brett Frischmann and Prof. Shoshana Zuboff on the online (zoom) panel discussion with the question – Should online targeted advertisement be banned on the premise that it violates human d…

Strengthening a cancer patient's own immune system so that the body itself can better destroy cancer cells. This is at the heart of immunotherapy, the most promising progress in cancer treatment in recent years. In order to drive this development further, the Netherlands Cancer Institute-Antoni van…

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Adenosine diphosphate ribosylation (ADP-ribosylation) is a fascinating post-translational modification (PTM) that plays a role in a variety of cellular processes and is associated with several diseases, including cancer and viral infections.

The authors detail the transnationality of terrorist organisations, including fundraising, communications, alliance-forming, movement and target selection.

Interest group Animal Rights has started a test case to prompt the Netherlands Food and Consumer Product Safety Authority (NVWA) to tackle farmers who do not adequately protect their livestock against wolves. The test case concerns a rejected enforcement request to the NVWA. In it, the NVWA were called…

The challenge is considerable, but so is the satisfaction when it succeeds: creating complex sugar molecules that play a role in biology.

The major aim is to develop, evaluate, and implement disease-generic cognitive-behavioral interventions through the internet in order to optimize tailored health care for patients with chronic somatic conditions.

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

ADHD&me is a new cognitive-behavioural therapeutic intervention for young adults (16–25 years old) with ADHD, specifically aimed at improving self-esteem. In this study, we are conducting a Randomized Controlled Trial (RCT) to examine whether this intervention improves self-esteem and whether related…

A deliberate attack on a tangible element of a culture, such as a temple, is often also an attack on intangible elements: the religion or religious customs. Equally, the intangible can be attacked without the involvement of the tangible, for example the brutal curtailment of rights. How are these reflected…

Nitrogen professor Jan Willem Erisman and Ton Brouwer have released a new report presenting scenarios to actually meet the agricultural nitrogen targets for 2030. Their message to politicians in The Hague: ‘Look at this approach — it is possible.’

Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

MT3 is a globally unique programme led by professors and expert authors that covers the most up-to-date knowledge possible in the area of Classical Transfusion Medicine and Cellular and Tissue Therapy. It provides access to high quality knowledge and skills via a completely online system.

Are you considering starting with the Master's Transfusion Medicine and Cellular and Tissue Therapies? Please feel free to contact us if you have any questions.

The United States has recently imposed sanctions on four more senior officials of the International Criminal Court, including Judge Prost, who is a Canadian national. Jens Iverson, assistant professor of international law, commented on this in The Globe and Mail, Canada’s national newspaper.

Six PhD candidates from the Institute for History took part in a pilot project targeted at career development. Between September and December 2016 group meetings and individual coaching sessions helped them position themselves better on the job market outside of academia.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.

The master's specialisation Child and Adolescent Psychology consists of three main parts: the mandatory and elective courses, a thesis and an internship.

Project TARGET is a research project aimed at the relation between the illegal arms trade and firearm violence. In a study conducted in seven countries, the researchers took a look at the differences and similarities. Katharina Krüsselmann and Marieke Liem took a closer look at the situation in the…

Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

Holocaust scholars Barbara Engelking and Jan Grabowski will jointly hold the Cleveringa lecture on November 26. They were accused of defamation in Poland for a book they co-edited. How has this affected them? ‘This is an attempt to wear us down.’

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The aim of our research program is to better understand the etiology and course of mood, anxiety and stress-related disorders, such as depression and posttraumatic stress disorder (PTSD). We investigate both the transdiagnostic mechanisms underlying these disorders and work on improving the treatments…

Tuberculosis causes 1.5 million deaths yearly and anti-tuberculosis therapies are threatened by emergence of drug resistance. Development of innovative drug combinations should be accelerated with the use of translational pharmacological models. Moreover, host-directed therapies (HDT), which stimulate…