A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Supervisor: Gerard van Westen

De Raad van Advies bestaat uit leden die een binding hebben met de faculteit. Daarnaast zijn zij goed thuis in de wereld van de advocatuur, de rechterlijke macht, de overheid en het bedrijfsleven. Het faculteitsbestuur gebruikt de adviezen van de Raad van Advies bij de beleidsontwikkeling van de faculteit…

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

Source: ChemMedChem (2015)

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Supervisor: Gerard van Westen

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

During the course of drug discovery translational steps are made.

Together with Pepijn Tuinier and Thijs Brocades Zaalberg, Sebastiaan Rietjens researched the role of trust in an international intelligence cooperation.

Leiden University is ending the experiment with the Binding Study Advice in the second year of the bachelor's programme (BSA 2) with immediate effect. Under the terms of BSA 2, students were required to obtain 90 credits within two years, including their first-year diploma.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

PhD defence

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

De Universiteit Leiden vindt de aanpassing van het bindend studieadvies geen verstandig plan.

Klare taal en betere regels rond geheimhouding. Dit zijn enkele aanbevelingen van Leidse onderzoekers om de toegang tot informatie te verbeteren voor burgers die procederen tegen de overheid. Bestuur en rechter moeten zo vroeg en zoveel mogelijk informatie delen.

The Advisory Council on International Affairs (AIV) has issued an opinion on possibilities for reform within the European Union (EU) in the area of Common Foreign and Security Policy (CFSP), the EU budget, and protecting the rule of law.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Intelligence scholars have been struggling to find the conditions under which international intelligence cooperation occurs. Most focus on transactional motives and guaranteed returns, the so called ‘Quid pro Quo’. At the same time, trust is often mentioned as one of the foremost conditions, yet it…

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

De asielplannen van minster Faber leveren de nodige commotie op binnen politiek Den Haag. Wilders wil geen enkele concessies doen en dreigt met verkiezingen. De Raad van State oordeelt nl. negatief op de wetsvoorstellen. Wim Voermans, zegt in Nieuwsuur dat ‘de plannen juridisch net binnen de lijntjes…

Α-synuclein, a protein associated with Parkinson’s disease, proves to bind with membranes in a surprisingly efficient way. It confirms scientists’ suspicion of the protein’s leading role in the transmission of neurotransmitters between nerve cells in the brain. Publication in PLoS ONE.

The United Nations Office for Disarmament Affairs (UNODA) has published the 2017 issue in their Civil Society and Disarmament series, titled Voluntary, Non-Binding Norms for Responsible State Behaviour in the Use of Information and Communications Technology: A Commentary. The series aims to provide…

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

From 3-6 December 2019 the conference “The Ties that Bind”: Mechanisms and Structures of Social Dependency in the Early Islamic Empire will take place. Deadline for sending in your abstract: 31 January 2019.

On this page you will find all information about the Bachelor of Security Studies that you need as a first-year student.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Students in Leiden are entitled to good teaching and good supervision. For their part, there are some conditions they have to meet to ensure that they complete their studies within the time allotted.

This thesis seeks to investigate how cancer-associated mutations affect the pharmacological properties of selected GPCRs—primarily A2AAR and 5-HT2CR—through a combination of ligand binding assays, signaling readouts, kinetic profiling, and cellular functional assays.

Promotor: M. Ubbink, Co-promotor: G. Siegal

‘Huis van het Boek/Museum Meermanno in The Hague exhibits book bindings by leading Dutch Art-Nouveau artists from the period 1890-1910. The exhibition will be open from March 22 to June 23 2019. The title of the exhibition is De Bijzondere Band: Art Nouveau-boeken van Dijsselhof, Lion Cachet en Nieu…

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

A special find has been made in the Alkmaar Regional Archive: a number of 17th-century book bindings contained pieces of parchment from a manuscript from the 11th century. The original manuscript may have belonged to a princess who fled England after the Norman Conquest.

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Promotor: J.P. Abrahams, Co-Promotor: N.S. Pannu

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

At Leiden University we believe it is important that you receive the right kind of support in your choice of study and while you study. This is why we use what we call the ‘Leiden study system’ to help you make a success of your study from start to finish.

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Promotor: M. Danhof, Co-promotores: J. Freijer, A. Yassen

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.