This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Anneleen van der Meer discusses Russia's alleged use of chemical weapons in Ukraine in an article for The Conversation.

The government spends millions regulating companies that work with large quantities of hazardous substances. But we don’t know whether this is making the industry safer. The number of violations and incidents remains constant. This is the conclusion of external PhD candidate Rob in ’t Veld in his dissertation.…

Vibrating carbon monoxide molecules adsorbed at the surface of a salt crystal stop moving after a few milliseconds. Scientists now discovered this is dominantly due to the emission of electromagnetic waves. The role of the chemical bond at the surface thereby appears to be less important than previously…

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

Is the quality of the current supervision and enforcement by the government such that companies that work with large quantities of hazardous substances are brought into compliance with legislation and regulations?

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

Testing chemical substances without using animals. It seems a utopia, but a European team is going to develop a way to make this a reality. The RISK-HUNT3R project, led by Leiden professor Bob van de Water, received 23 million euros from the European Commission for this purpose. The project was launched…

What chemicals do plants have available, and what happens if they use them when faced with bacteria or fungi? That is what PhD candidate Luis Salomé Abarca is keen to learn. He studies plants’ survival and their use of chemical components in communication and defence. Salomé Abarca works at the Natural…

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

An international team of researchers, including Federico Calle-Vallejo of Leiden University’s Institute of Chemistry, have taken the atomic-scale design of catalysts to the next level. Their research contributes to the quest for a method to generate or store energy more efficiently. The report is published…

Doğukan Yilmaz chose a study that aligned with his favourite subjects, and it paid off. For his bachelor thesis, he developed a new model to better predict an important chemical reaction. ‘On the edge of what is possible at the bachelor level,’ his supervisors write. Thanks to his impressive achievements,…

A group of chemists, that includes Sander van Kasteren and Hermen Overkleeft, has discovered that azides, a certain type of chemical compound, can determine whether or not T cells respond to or ignore a vaccine. Their discovery is set to be published in Angewandte Chemie.

Plant exudates appeared long time ago in the history line of life in the early Devonian. They are typical saps produced by specialized cells.

Thomas Bakkum en Tom van der Wel, two PhD candidates from the Leiden Institute of Chemistry, have both won poster prizes at the EMBL Chemical Biology Conference 2018 in Heidelberg.

The Dutch chemical industry is regularly in breach of safety legislation. These are the findings of longitudinal research by the Department of Criminology at Leiden University, in collaboration with the Department of Criminology at VU Amsterdam. Over the past ten years, the roughly 400 companies to…

One of the holy grails of drug research is to be able to assess the safety of chemicals and pharmaceuticals without using laboratory animals. Researchers from Leiden University, among others, now receive a grant from the National Science Agenda to pursue that goal.

If you could convert CO2 into building blocks for other molecules with the help of electricity, you could make the chemical industry considerably more sustainable. Leiden chemists have unravelled a fundamental part of this process and applied this knowledge in a real device, as they write in Nature…

The American Chemical Society’s Publication Division (ACS) and Dutch universities represented by the VSNU have reached agreement on including open access publication as part of the contract with publishers. From 2017, all new articles submitted by an author associated with a Dutch university or participating…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

Promotor: Prof.dr. J.W.M. Frenken

As of 1 July, toxicologist Mirjam Luijten from the Dutch National Institute for Public Health and the Environment (RIVM) starts as professor by special appointment at the Leiden Academic Centre for Drug Research (LACDR).

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Predictors of work functioning in persons with multiple sclerosis

Sander van Kasteren only noticed some small, subtle changes since he was appointed professor on 1 May. Still, he has to get used to the idea, even though he had been working towards the professorship for a few years. ‘I don't quite see myself as a professor yet.'

An international team of astronomers has revealed the first 'chemical profile' of an exoplanet's atmosphere. The team, including Leiden astronomer Yamila Miguel and provenda Amy Louca, made the profile using so-called Early Release Science data from the James Webb Space Telescope. The results have been…

The Dick Stufkens Prize 2018 for the best PhD thesis of the Holland Research School of Molecular Chemistry (HRSMC) will be awarded to Dr Stefan Vuckovic. In his thesis, Vuckovic presents a new and innovative approach to the quantum mechanical calculation of atomic and molecular energies. It lays the…

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

Pesticides can form a toxic cocktail when they occur in combination in surface water. This is the finding of research that Leiden University and the Dutch National Institute for Public Health and the Environment (RIVM) presented on Monday 14 October. The Dutch Ministry of Infrastructure and Water Management…

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

The bacterium Vibrio cholerae is a serious threat to our health because it is the causative agent of cholera. Worldwide, over a billion people per year are at risk of cholera infection. New strains of V. cholerae are resistant to the multiple drugs used to treat cholera, meaning that new types of drugs…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

A difficulty of studies on chemical kinetics are the reaction time scales and detection of their intermediates.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…