We aim to understand ion homeostasis in the model eukaryote S. cerevisiae.

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Examining mediation and moderation.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The Leiden Institute of History approaches early modern and modern European history from comparative and transnational perspectives.

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

This dissertation provides an account of polar questions in Italian dialects from a typological, theoretical and empirical perspective.

Investigating specific language and speech behaviour of people.

This article assesses Russian rhetoric toward Ukraine from 2004 to 2019 by analyzing statements by the Russian Ministry of Foreign Affairs.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Each month, we publish an article showcasing how social science research and education contribute to solving societal challenges. Researchers, lecturers, students, and societal partners work together to make knowledge accessible and to make a difference. Through open science and engaged education, we…

PhD defence

The first of April was the official start of Phase II of the collaborative “PCAD4Cod”-project on the effect of sound on fish populations. Hans Slabbekoorn, associate professor at the IBL, is the principal investigator and collaborates with three PhD-students, Dr. Erwin Winter, (Wageningen Marine Research),…

Adva Eichengreen starts a fellowship focusing on enhancing social participation of deaf and hard-of-hearing (DHH) children. Eichengreen has been offered a postdoc position at Leiden University as part of the Marie-Sklodowska-Curie “LEaDing Fellows” Project within the collaboration of the Leiden-Delft-Erasmus…

The Dutch Research Council (NWO) awarded behavioural biologist Hans Slabbekoorn (Institute of Biology Leiden) a grant of 750,000 euros to study fish and sounds around wind farms in the North Sea.

Hans Slabbekoorn, researcher at the Institute of Biology Leiden, is one of the editors of the latest volume of the Springer Handbook of Auditory Research (SHAR). This book is filled with everything known about the effects of sound on vertebrates. Slabbekoorn’s contribution to the book as a co-author…

Living systems scale from unicellular microbes to complex multispecies communities that constantly change over time. Within the theme Development & Disease, we enhance our fundamental understanding of development and homeostasis of living cells and systems. We analyze the normal situation and how stresses…

A novel in vivo model system for studies on glucocorticoid resistance

Promotor: P.M. Brakefield

This project is aimed at 1) elucidating the role of attention in itch and pain, including orientation, and attentional disengagement (i.e., directing attention away) from itch and pain; and 2) modifiability of these attentional processes.

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I think we should go this way. This way! THIS! WAY!! Making yourself heard in a city can be difficult. That is not only the case for humans, but birds seem to be hindered by urban noise as well. Researcher Hans Slabbekoorn of Leiden University already showed that great tits in Leiden communicate differently…

Plant Sciences' contribution to the Biodiversity & Evolution research theme is to understand what are the key drivers of plant biodiversity during evolution with a focus on plant life history and resilience traits and develop tools to restore and maintain plant biodiversity.

Sasse, van Breen, Spears & Gordijn demonstrated an anger gap in response to sexism which was larger for women than for men and found evidence that expressed anger was associated with instrumental concerns.

In this project, we plan to combine two strands of research in speech processing: (a) the impact of prosody on speech processing and (b) the impact of musical training on speech processing. In our project we will test 8 year-old children with different degrees of musical training: (a) primary school…

The Risk and Regulation Lab from organises events and workshops in Leiden and The Hague. On this page you can read reports of the events that already took place.

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Molecular Physiology is a research group at the Leiden Institute of Chemistry dedicated to the design, synthesis and application of chemical tools to study important biological and biomedical questions. The group is headed by Prof. Dr. Mario van der Stelt and includes the research lines of Assistant…

Can a virtual character’s friendly non-verbal responses stimulate eye-contact in individuals with varying levels of social anxiety?

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

Research of the Methodology & Statstics unit of the Institute of Psychology at Leiden University.

Social Information Processing in Children with and without Hearing Loss

Supervisor: Gerard van Westen

In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

This dissertation examines whether a cochlear implant provides congenitally deaf born children with sufficient auditory input to acquire low salient and syntactically and semantically complex functional items such as personal pronouns compared to their hearing peers.

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

When we are in a conversation, how do we know exactly when to respond, and how do we manage to respond so swiftly, yet without interrupting our interlocutors? Can speech melody – in particular utterance final “boundary tones” – help us determine who will speak next, or are these cues too late in the…

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

The CIGR comprises research groups from the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

Key publications of the Medical Systems Biophysics and Bioengineeringgroup (Mashaghi Lab)

The Physics and Biological and Soft Matter master's specialisation is one of the two programmes that Leiden University offers in experimental physics. This programme mainly focuses on Biological Physics and Soft Matters Physics.

Which plant leaf characteristics are involved in thrips resistance in tomato?