Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Beenakker

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Can light-activatable ruthenium compounds be used as a more selective anticancer treatment?

The elementary excitations of magnets are called spin waves, and their corresponding quasi-particles are known as magnons. The rapidly growing field of Magnonics aims at using them as information carriers in a new generation of electronic devices, (almost) free of electric currents.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The plant hormone auxin regulates plant growth and development through polar cell-to-cell transport-generated maxima and minima. PIN FORMED (PIN) auxin efflux carriers determine the direction of this auxin flow through their asymmetric placement on the plasma membrane (PM).

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Examining if large scale application of new energy pathways can be constrained by materials and emissions.

Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

The SAPPAO project aims to optimise the accuracy and reliability of predicting scheduled flight times. The full name of the project is 'A Systems Approach towards Data Mining and Prediction in Airlines Operations'.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Control of infectious diseases poses continuous challenges for human health.

This project investigates the professionalisation of university libraries in the nineteenth and early twentieth centuries, through the lens of the medieval manuscript holdings. Taking Leiden University Library as a starting point, it sheds light on the changing practices surrounding the conservation,…

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.

The polypept(o)ide hybrid material attracted more and more attention over the past decade by combining the multifunctional characteristics of polypeptides with the shielding characteristics of polypeptoid-pSar possessing similar properties as a shielding material as polvethylene glycol(PEG). Polysarcosine…

With the rise of information and communication technologies, large amounts of data are being generated and stored in databases. In order to get a better grip on these large amounts of data, serious efforts are being made to discover patterns and relations in the data with the help of new techniques.…

Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?

Eduard Fosch-Villaronga, Marie Skłodowska-Curie Postdoctoral Researcher at eLaw- Center for Law and Digital Technologies, just published a book on Robots, Healthcare, and the Law. Regulating Automation in Personal Care.

A full overview of MCBIM PhD theses.

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

What is the optimal investment policy according to which a firm adapts its capacity in a competitive market?

Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

PBDL favors multidisciplinary research. Depending on the problems under investigation, PBDL establishes collaborations between experts from for example molecular genetics, molecular and electro cell physiology, biochemistry, organic chemistry, analytical mathematics, mathematical statistics and computational…

The following page offers tips for more sustainable travel options, such as taking the train or bus, and highlights online tools that can help you plan eco-friendly trips and find affordable tickets.

Research groups in the Quantum Matter & Optics programme investigate electronic properties of matter and light-matter interactions with emphasis on quantum information.

The Immune Activation and Tolerance group is headed by Dr. Bram Slütter. Vaccination is an experimental, but promising, treatment strategy for atherosclerosis. Previous work has shown that immunization of mice with modified LDL particles can reduce atherosclerotic lesion development, however such vaccines…

From research on stellar winds to sign language: an impressive seven researchers from Leiden University will receive a prestigious Vici grant from the Dutch Research Council (NWO).

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Asian Studies at Leiden University is unparalleled in the Netherlands and combines the very best of Asia-related research in North-West Europe.

See below for the full programme and abstracts of all papers.

Dutch and foreign alumni from Leiden are the oil that keeps the wheels of Dutch-Asian relations moving smoothly. That’s one of the conclusions reached during the area day of the Dutch ambassadors in Asia and Oceania. All of them gathered in Leiden University’s Academy Building on 30 January.

Exactly a century ago, astronomers observed the first two diffuse interstellar bands (DIBs) in space. A DIB manifests itself as a colour of light that is missing in the radiation from stars behind an interstellar cloud. Although about 500 DIBs are yet discovered, they remained inexplicable until recently.…