The Green Office wants to help start a community garden in the open patio space of the Schouwburgstraat buiding in the Hague.

Since the end of the nineteenth century Arabic book designers have influenced the social and cultural situation in the Middle East with their work. Huda Smitshuijzen Abi-Farès has written the first global overview of this neglected field of science. PhD defence 10 January.

The Leiden Academic Centre for Drug Research (LACDR) is responsible for the research and education in Bio-Pharmaceutical Sciences carried out at Leiden University.

Robert Ietswaart does research into gene regulation at the famous Harvard Medical School in Boston. He developed an algorithm to better predict whether a candidate medicine is going to produce side effects. He studied mathematics and physics in Leiden, and gained his PhD in computational biology in…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Conference

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

Chemotherapy that does not harm the body, but effectively fights cancer cells: that is the goal of chemist Sylvestre Bonnet and his team. During his PhD research, chemist Xuequan Zhou brought that goal a little closer. He developed molecules that, upon injection in the bloodstream, self-assemble into…

Rosan Kuin started her PhD in July at the LACDR under supervision of prof. Gerard van Westen and Dr. Meindert Lamers. She completed a BSc. in Pharmaceutical Sciences at the VU University in Amsterdam in 2017. After that she started two master programs, Drug Discovery & Safety with a specialization in…

This case study demonstrates how to design and effectively deploy a (survey embedded) conjoint experiment.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

On May 18 Janneke Wesseling gave a lecture at the conference

This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

Spatial analysis on the basis of material culture has always been one of the major topics in archaeological research. Designating Place analyses the urban space of Roman Ostia and Pompeii in different ways, namely via geophysical analysis, spatial analysis, iconographic analysis and epigraphic analy…

In this article, Wout Broekema, Wouter Jong, and Sara Perlstein explore the design and assessment of crisis inquiries from a learning perspective.

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

Design and synthesis of two 3-substituted swainsonine derivatives with the aim to improve the potency and selectivity towards Golgi alpha-mannosidase II.

Arco Timmermans, Professor by special appointment Public Affairs at Leiden University, brought sience to practice by designing an “ideal” academic education programme on public affairs, to be embedded and taught at the graduate level.

Promotor: J.N. Kok, Co-promotor: F.J. Verbeek

As part of the Leiden Heritage Deal, the Municipality of Leiden collaborates with Leiden University, Naturalis, and the Leiden Regional Heritage Office, to study the climate challenges facing the city centre and its historic green and blue networks. The goal is to contribute to a biodiverse, climate-resilient…

This thesis advances our understanding of lipid uptake, a vital first step in lipid metabolism, by developing innovative click chemistry-based tools to study how immune cells internalize lipids.

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Time-series forecasting through modelling sequences of temporally dependent observations has many industrial and scientific applications. While machine learning models have been widely used to create time-series forecasting models, creating efficient and performant time-series forecasting models is…

What does it mean to do “global research”? Global studies is an emerging field that focuses on transboundary, international, and global processes and systems, such as climate change, global social media, and globalization. These issues call for researchers to think beyond conventional state actors or…

With the What's Next? series we hope to inspire current Media Technology MSc students, show the variety of paths taken after the studies, and bring together alumni. Editions of the series are generally organized around a particular theme by Media Technology MSc students themselves, and followed by social…

Students from the Royal Academy of Art The Hague (KABK) designed the 450 lustrum logo.

Children, cardiac surgery patients or people who are obese. How can we improve the dosing of painkillers for these patients? Hospital pharmacist Sjoerd de Hoogd of the St. Antonius Hospital in Utrecht investigated this. He combined data from the hospital with the knowledge and expertise of the Leiden…

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Premature babies almost always require treatment with medication. Doctors usually determine the dosages based on data from children who were not born prematurely, while preterm infants often develop differently. Medication researcher Aline Engbers investigated three commonly used drugs, focusing on…

Graphene and other layered materials combine into completely new substances. Leiden physicists establish the ground rules for designing such materials by measuring how the layers in the stack interact. Publication on November 29 in Nature Communications.

Hackers and Designers Summer Academy 2020 will take place remotely from July 20-25

The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…

On 8 April 2022, Jan Aart Scholte gave a keynote lecture on ‘Multistakeholderism: Prospects of an Institutional Design’ at the T.M.C. Asser Institute.

Since the start of the Corona crisis, several COVID-19 related research and teaching projects were started at LACDR. The computational and teaching activities started right away, as well as a large-scale metabolomics screening program by Thomas Hankemeier’s group. Other experimental activities are still…

The METIS instrument that’s being built for ESO's future Extremely Large Telescope (ELT) in Northern Chile under the leadership of the Dutch Research School for Astronomy (NOVA) has reached an important milestone: the preliminary design has been approved.

Modern optimization algorithms offer solutions for architectural decisions like spatial, structural and energy efficiency. A young computer scientist from Leiden University co-authored a paper that won the Best Paper Award at a leading conference in Krakow during the summer.

A new computer simulation shows the promising possibilities of the booming field of topology. Smartly designed mechanical structures carry sound exclusively one way and are immune to fabrication errors. Publication on 17 July in Nature Physics.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

With the What's Next? series we hope to inspire current Media Technology MSc students, show the variety of paths taken after the studies, and bring together alumni. Editions of the series are generally organized around a particular theme by Media Technology MSc students themselves, and followed by social…