Which brain cell does what, when Parkinson's disease arises? It won't be long before this jigsaw is solved piece by piece. Ahmed Mahfouz, computational biologist, combines bio-knowledge from Leiden with algorithms from Delft and is getting closer to finding the key.

The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Steffen Brünle's group investigates G protein-coupled receptors (GPCRs). These essential membrane proteins are prime targets for therapeutic drug development in disease and cancer treatment.

Lots of efforts are being made to promote open science practices in scholarly publishing. However, information on the openness of scholarly journals is highly fragmented. There are various data sources that provide information on specific aspects of openness, but there is hardly any integration of these…

Why is there not just one single global law for cases of defamation in cross-border communication mediums such as the internet? Which courts are to be called on in such cases? And is it permissible to hold an intermediary instead of a content provider liable?

An accurate description of reactive scattering of molecules on metal surfaces often requires the modeling of energy transfer between the molecule and the surface phonons. Although ab initio molecular dynamics (AIMD) can describe this energy transfer, AIMD is at present untractable for reactions with…

The van Exter group has an extensive history of prior research in classical and quantum optics. As former part of the group of Han Woerdman, we have studied topics as diverse as:

This minor is developed for third year students and is only accessible for bachelor students who have obtained their ‘propedeuse’, we are sorry to tell you HBO students cannot apply.

How did interests outside the scope of the Dutch chartered trading companies influence the career-paths of Dutch colonial governors?

The LUCAS Institute has both a new Scientific Director and a new Education Director. Stijn Bussels and Esther Op de Beek both commenced their new roles at the start of the academic year.

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

How to come to valid risk stratification of alcohol use disorder?

Research question

North, Middle and South America together constitute the single largest area in World Archaeology that is taught as a single focus. It is also the only major world area that saw societies develop from hunter-gatherers to early empires entirely independent from developments in Eurasia & Africa. It is,…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

The Hazelhoff Centre for Financial Law team regularly publishes in both Dutch and international academic journals and book series.

How do plant defense genes get activated?

The Western Mediterranean is a key region to understand human dispersal events within and out of the African continent as well as for the eventual replacement of Neanderthals by anatomically modern humans during the Pleistocene. Central to any conclusive interpretation of archaeological and palaeoclimatic…

High throughput microscopy

Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:

Product packaging is essential. It prolongs shelf-live and highly influences purchasing decisions. However, it’s also a big source of waste, especially single-use plastic. Have you ever felt conflicted choosing a product due to the material it’s packaged in? Or opted for a different product due to its…

The aim of this project is to develop accurate but interpretable ensemble learning methods for high-dimensional multi-domain data.

Quantum computing is an emerging technology, which holds the potential to simulate complex quantum systems beyond the reach of classical numerical methods.Despite recent formidable advancements in quantum hardware, constructing a quantum computer capable of performing useful calculations remains challenging.In…

Chair of LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University - the Netherlands

Caminada et al. examine elderly poverty across 16 European countries (2005-2022).

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

An environmental and palaeo-economic reconstruction.

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This thesis describes the importance of being able to control the selectivity of potential drug candidates.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

Promotor: M.A.G.J. Orrit

The idea of citizens and public professionals collaborating to provide public services has widely spread in several countries around the globe. Co-production is often presented as the go-to solution for challenges like a legitimacy crisis of both the government and the market, and financial concerns.…

On 10 October 2018, Richard Resch defended his doctoral thesis 'The Interpretation of Plurilingual Tax Treaties'. The doctoral research was supervised by Prof. mr. C. van Raad.

Assistant Professor at the Department of Analytical Chemistry, Radboud University Nijmegen, the Netherlands

Homicide followed by the suicide of the perpetrator often leads to shock and incomprehension. It has been suggested that media reporting on such cases could lead to an imitation effect.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

In this dissertation, we work towards an experiment in which we aim to bring a micrometer sized magnet at the tip of a soft cantilever into a superposition.

Prior to the 2020 presidential election, historians considered the disputed 1876 contest—which pitted Republican Rutherford B. Hayes against Democrat Samuel J. Tilden—the most controversial in American history.

This is the physics summer school of Leiden University. It is part of the Leiden Institute of Physics (LION). The summer school is intended for Bachelor (BSc) students in physics. It covers topics from quantum matter and optics, to biological & soft matter physics and cosmology and theoretical physics.…

The remains of Dutch East India Company forts are scattered throughout littoral Asia and Africa. But how important were the specific characteristics of European bastion-trace fortifications to early modern European expansion?

Scientific research is the main focus of our program. We expect new students to understand what it is and how it works.

ERC Starting Grant: The Van Manen Project. This five year project (2023-2028) is made possible with an ERC Starting Grant. It aims to (digitally) reunite all parts of the Van Manen Collection. This enables us to study it as a whole, helping us to understand the process of collection formation. More…

The Cambridge Studies in International and Comparative Law is the leading general series for monographs in international law which will celebrate its 70th anniversary next year.

The Catholics were by no means pitiable victims over the two centuries that they had to practise their religion underground, Caroline Lenarduzzi writes in her PhD dissertation. They managed to keep their faith alive from the mid-sixteenth to the mid-eighteenth century. PhD defence 25 October.

Alexander Kros studies supramolecular systems in a biological environment. The unifying theme between the projects in my lab is specific molecular recognition, i.e. the intermolecular interaction between complementary molecules with high affinity and selectivity. Studying, imitating and dissecting processes…