During the Summer School Science Communication, you will learn everything about science communication.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Are you a researcher eager to share your work with a broader audience? Do you want to develop your science communication skills and learn how to engage effectively with society? Then join our Summer School in Science Communication in Leiden from 6-10 July 2026! Jointly organized by the Faculties…

Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

An integrated approach for the simultaneous prediction of polypharmacology and binding affinity/potency of small molecules.

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The Biomedical Sciences Communication specialisation focuses on the interaction between science and society and concerns science communication in a broad sense. You combine your research training with different aspects of science communication. The entire programme is taught in English.

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

The research group Science Communication and Society has been physically within the Institute of Biology (IBL) since 2012 and has become a formal part of the institute in 2018. The mission of this group is understanding how science communication works to improve the interaction between science and s…

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

OSCL is a learning community where anyone associated with Leiden University can learn and talk about open science practices. Example events are Open Science cafés, workshops, and walk-in-hours. The what Open science is an umbrella term for an approach to science that aims to make scientific…

The master’s specialisation Computer Science and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in computer science with extensive training in science communication.

Discovery of metastasis promoting candidate drug targets

A next, general pharmacological problem to be tackled is how drug-target binding kinetics in vivo, affects target occupancy as an important indicator of the time-course of drug effects.

To strenghten ties with the public, press, other academics and wider society, LION employs an outreach officer.

Are you interested in combining your master programme with the Science Communication and Society specialisation? Learn more and watch the introduction video.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

To assess the impact of illicit firearms trafficking on gun violence, this research looks at the scope, characteristics and contexts of firearm violence, and also the scope and nature of firearms trafficking in Europe since the new millennium. Nils Duquet, Dennis Vanden Auweele and Marieke Liem created…

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

The master’s specialisation Physics and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in biology with extensive training in science communication.

The master’s specialisation Biology and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in biology with extensive training in science communication.

The master’s specialisation Bio-Pharmaceutical Sciences and Science Communication & Society at Leiden University is a two-year programme which combines research training in chemistry with one in techniques of communication.

The master’s specialisation Astronomy and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in biology with extensive training in science communication.

The master’s specialisation Mathematics and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in mathematics with extensive training in science communication.

Understanding DNA repair mechanisms is essential for advancing plant biotechnology and crop improvement. This study investigates how double-strand breaks (DSBs), induced by CRISPR/Cas systems, are repaired in the model plant Arabidopsis thaliana, and how these processes influence Agrobacterium tumefaciens…

Join the OSCL community to share your experience and learn more from others at Leiden University

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Read more about the International Network Open Science & Scholarship Communities in our Vision and Mission statements.

On 27 May 2021, Hirad Abtahi defended his thesis 'Adjudicating Attacks Targeting Culture'. The doctoral research was supervised by Prof.dr. C. Stahn.

Unravelling networks of human mobility and exchange of goods and ideas from a pre-colonial, pan-Caribbean perspective

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

Project TARGET aims to improve our understanding of gun violence in Europe and the relationship between gun violence and firearms trafficking.

How can we bridge the gap between experts and the general public?

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Change requires community. Become a member of OSCL today!

The community & communication workgroup serves as an umbrella that – in addition to its own activities – works with all three workgroups on the community and communication related aspects of their activities