Some examples of AI-research done at Leiden.

There are several training oportunities within the cell observatory

Astronomer and Marxist Anton Pannekoek was a remarkable figure. This book aims to study the connections between his life as a socialist theorist and as a pioneering scientist through the prism of Pannekoek's biography.

Vancomycin is a last-resort antibiotic for the treatment of many Gram-positive bacterial infections, while remaining inactive against Gram-negative strains.

Promotor: G.P. van Wezel

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

My work focuses on a class of astronomical objects called protoplanetary disks.

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

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Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

High-angular-resolution observations of the circumstellar material have uncovered numerous and very diverse substructures in protoplanetary discs, raising the question of whether they are caused by forming planets or other mechanisms.

Promotor: Prof.dr. G.P. van Wezel

For each living organism health is ensured by correct functioning of its cells. Cells therefore have elaborate methods for regulation of their proteins.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Fijs van Leeuwen, Professor of Radiology, Molecular Imaging and Image-Guided Therapy, advocates an open and respectful academic culture that always puts the patient first. He delivered his inaugural lecture on 13 November.

Two Leiden projects have been awarded Open Science NL funding to make science more accessible to academia and the world outside. The projects will strengthen the open science infrastructure.

Outflows are crucially important for the gas budget and evolution of luminous star-forming galaxies and AGNs, with observed mass outflow rates of the same order as the star formation rate. Greater star formation and black hole growth lead to more intense feedback and outflows, resulting in self-regulated…

Organic molecules in interstellar space are important as they influence the structure of galaxies and star formations. Studying catalytic processes in space allows us to understand how molecular species are formed and chemically evolved in the interstellar medium and solar system objects.

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Data science is now growing fast in many places, but scholars at Leiden University have been developing data science techniques for a long time already. Thanks to their broad-based expertise, Leiden statisticians are currently combining the achievements in statistics with the latest methods of statistical…

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

Study information

Study information

Study information

After many years, Peter Hamersma will retire and resign as Programme Director for the BSc Molecular Science & Technology. His successor is Volkert van Steijn, who will start this new challenge per September 1st.

PhD candidates carry out a programme of independent research and additional limited) course work, culminating in production of a PhD thesis in typically 4 years.

Festival

The Faculty of Social and Behavioural Sciences provides its ca. 5000 students with a thorough education in the social and behavioural sciences. The student population is very diverse and international in nature.

The central aims of MicroClock project are to describe the B. subtilis circadian clock at molecular and functional levels, and discover the mechanisms of clock-regulated bidirectional signaling between B. subtilis and the model plant Arabidopsis

No less than 172 international master students coming from 30 different countries visited the Faculty of Science on 29 August during the OWL: the Orientation Week Leiden.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)