The imaging group focuses on bio-imaging, image analysis and visualization.

For more information regarding ongoing research projects, please contact Prof. Miranda van Eck.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

The online exhibition 'Art of Captivity' corresponds with the publication of anthropologists Kevin Lewis O'Neill and Benjamin Fogarty-Art Valenzuela's book the Art ofCaptivity (University of Toronto Press 2020).

The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

The impact of the phenotypic plasticity of P. aeruginosa and the distinct CF lung microenvironments on antibiotic drug effects and resistance remains poorly understood.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

Allosteric modulation has long been recognized as a general and widespread mechanism for the control of protein function. Modulators bind to regulatory sites distinct from the active site on the protein, resulting in conformational changes that may profoundly influence protein function. This concept…

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

On Wednesday the 4th of September, Queen Máxima opened the renovated tropical greenhouse complex of the Leiden Hortus Botanicus. At the occasion Máxima met with IBL-PhD student Mahin Ghorbani from Iran and talked with her about her work on drug discovery from Iranian medicinal plants using zebrafish…

A consortium of research groups, including that of LACDR professor Erik Danen, will use an NWO Perspective grant of nearly five million euros to build a universal standard for organ-on-chip models. They aim to stimulate the application of these chips in the biomedical and pharmaceutical industry. Danen…

The €6.24 million EU-funded research project QSPainRelief has kicked off. The project aims to help patients suffering from chronic pain with novel, personalised combinational treatments and is coordinated by Elizabeth de Lange from the Leiden Academic Center for Drug Research.

Though tuberculosis can be cured today, new resistant strains of the bacteria are becoming a growing problem in the medical world. Biologist Annemarie Meijer and her colleagues are studying resistance to this disease. Their research is already yielding several interesting clues that could help the development…

The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…

Source: Biochem Pharmacol, Volume 95, Issue 4, pp. 290-300 (2015)

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

Development of Comprehensive and High-throughput metabolomics techniques and Clinical applications of (pharmaco)metabolomics

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?

In this dossier you can read about Leiden University’s commitment to sustainability.

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

What is the most effective way to eliminate tumour cells? The DNA repair mechanism could play an important role in increasing the effectiveness of chemotherapy in the fight against cancerous cells. If we are to influence this mechanism, we need fundamental knowledge about how the mechanism works.

Research at the MCBIM group is comprised of the following research themes:

From molecule, to cell, to organism. The high-level drug research at the Cell Observatory aimes at reducing the spread of cancer and developing new medicines for tuberculosis.

Source: Mol Pharmacol, Volume 87, Issue 2, pp. 305-13 (2015)

To address major societal challenges, research needs to go beyond the boundaries of traditional disciplines. We believe this starts with education. By exposing students to people from different scientific fields, they learn to deal with diverse perspectives and can broaden their horizons. Professors…

The master’s specialisation Bio-Pharmaceutical Sciences and Industrial Pharmacy at Leiden University examines safety and quality control in the production of medicinal products, and prepares students for a career in Quality Assurance and Quality Control in the biotechnological and pharmaceutical ind…

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine.

Research at the SBC group is comprised of the following research themes:

Source: Bioorg Med Chem, Volume 23, Issue 14, pp. 4034-49 (2015)

Did he dare take a gamble with his PhD research? Jeroen Methorst didn’t have to think long about it. It could fail or turn out very well. The latter is the case. Methorst developed a computer system that helps researchers find the protein they need. ‘Our whole group is now using this program.’ Methorst…

Leiden chemists have proposed a new model for enzymatic reactions, in which the flexibility of the substrate is much more important than previously thought. Their results are paradigm-shifting and could have major implications for drug research and enzyme engineering. Publication in Angewandte Chemi…

Learn to program, gain knowledge of AI methods, or use it in a research project at the LACDR. With the introduction of the innovative digital learning environment ‘Digital Labcoat’, Biopharmaceutical Sciences bachelor students can further develop their computational skills.

The European Homicide Monitor (EHM) offers a standardized framework for countries and regions to compare homicide characteristics, patterns and trends.

Before patients can take a pill, scientists often spend years in the lab developing and testing a candidate drug. That often includes experiments with laboratory animals. As head of the rodent facility, Ilze Bot and her colleagues ensure that these experiments are conducted in an ethically responsible…

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Cardiovascular diseases are still a major concern for the global health.

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…