Promotor: B. van de Water

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotores: W. Jiskoot, F. Ossendorp

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Conference

M. Danhof, Co-promotor: O.E. Della Pasqua

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Source: Eur J Med Chem (2015)

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Atopic dermatitis (AD) is a common inflammatory skin disorder characterised by various epidermal alterations. Filaggrin (FLG) mutations are a major predisposing factor for AD and much research has been focused on the FLG protein.

Contact the Graduate School of Science Office

The Research in Bio-Pharmaceutical Sciences specialisation consists of compulsory and optional components.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…

Source: J Cheminform, Volume 7, Issue 1 (2015)

Supervisor: Indira Nederpelt

Metastasis is responsible for over 90% of cancer-related deaths and arises from the ability of a small subset of tumor cells to detach from the primary tumor, overcome multiple biochemical and mechanical barriers, disseminate through the body, and colonize distant organs.

Despite recent advances in medicine, many devastating disorders like cancer and cardiovascular, neurodegenerative and infectious diseases still lack effective treatments. In order to address this challenge, we, as scientists from Leiden University, joined hands in the LED3 network. LED3, for Leiden…

The Business, Technology & Public Policy research group of the Department of Business Sciences at Leiden University focuses on investigating the dynamic interaction between 'new' technologies and various stakeholders, including consumers, employees, and businesses. Our research delves into perceptions,…

Other COI publications can be found on Leiden Law Blog, the Leiden Law Methods Portal, and in the drop-down tabs below.

Which features characterize speakers’ voices, and how are these features determined by what a speaker is saying?

The Institute of Education and Child Studies aims to create a challenging academic environment in which students can flourish.

The programme group Research Methods and Statistics develops and teaches the large majority of methodological courses in all phases of the program Education and Child Studies.

The Leiden Institute of Chemistry organises and participates in several programmes for high school students and teachers.

We live in a world of things and people in the past must have been as closely entangled with their material surroundings as we are now. In the Laboratory for Artefact Studies Van Gijn takes a close look at the biographies of objects: what kind of raw material an object is made off and what is its provenience,…

Explore philosophical research and education at the Leiden Institute for Philosophy. Our scholars study knowledge, ethics and existence, connecting classical and contemporary thought.

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On 22 June, Anneke Koning defended the thesis 'Return to sender: a multi-method study of guardianship against transnational sexual exploitation of children'. The doctoral research was supervised by Joanne van der Leun, Masja van Meeteren and Johan van Wilsem.

LUCSoR has chairs in Comparative Religion, Islam in the West, Christianity, and Judaism. Main areas of expertise include ancient Mesopotamian religions, the Enlightenment, Islam in the West, and new spiritual movements.

Now that you are aware of your master’s admission requirements, it's time to check the application deadlines.

Get to know us through our online and in-person events for prospective students!

Tim Koopmans is one of the great minds in the history of Dutch and European legal scholarship. He taught law as a professor in Leiden and other universities, among which Ghent, Cambridge, Utrecht. He practiced it as a judge in the European Court of Justice and Advocate-General in the Dutch Supreme Court,…

Linguistic research on a unique collection of Dutch letters allowed us to gain access to the every-day language of people from various walks of life. Private letters by men, women and even children have been elaborately explored in the Letters as Loot researchprogramme, initiated and directed by prof.…

Leiden University encourages all its laboratories to obtain LEAF (Laboratory Efficiency Assessment Framework) accreditation.

The need for novel drugs as well as innovations in their development and application is as urgent as ever. Below we present our vision , mission, and our key research areas.

The goal of pre-clinical development is to bridge the transition from lead compounds to clinical candidates by comprehensively characterizing safety, efficacy, and pharmacological properties. Once a lead compound demonstrates promising activity in disease models, it enters pre-clinical development where…

LED3 is the combined effort of four excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the institutes.

The central research question focuses on identifying shifts in the urban social network in terms of private, semi-public and public space by means of mapping the spatial distributions of wells and cesspits in the town of Haarlem in the course of the pre-industrial period (1200-1800). Shifts may be indicative…

Both good employer practices and good employee practices are open norms. These open norms can lead to uncertainty about what employers should focus on and what rights (and obligations) employees have in that respect. The objective of this study is to give substance to the norm of good employment practices…

How can teachers best learn from each other and develop? Jacobiene Meirink is conducting research on professional development for teachers in secondary education. She is particularly interested in how teachers collaborate on and learn from the development of teaching programmes. More insight into effective…

In our HANDS!Lab for Sign Languages and Deaf Studies, we run projects pertaining to sign language linguistics with a focus on Africa. In addition, we are running projects on sign language teaching, tactile signing, deaf people’s experiences with the legal system, and deaf history.