Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

ISBA2025

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

A juvenile suspect has been apprehended for the murder of 15-year old Megan from Breda last Monday. A highly unusual situation, according to Marieke Liem, Associate Professor at the Institute of Security and Global Affairs in The Hague. She gave an interview to Dutch newspaper AD.

Stay tuned for updates on relevant media appearances of Marieke Liem.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

On Wednesday 26 June, Marieke Liem, Associate Professor Physical Violence and Public Order at Leiden University’s Institute of Security and Global Affairs (ISGA), appeared on both Dutch radio programme ‘Nieuws & CO’ and the eight o’clock television news (NOS) to discuss life imprisonment.

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

For a successful implementation of an educational reform, teachers need to regard the proposal as being practical. I used a modular, success-oriented approach to make a context-based reform practical for implemtentation in Duthc biology education. educational reform, modular, teachers, biology, success-oriented,…

Promotores: H.A. Udo De Haes, P.M. Brakefield

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Lex Bohlmeijer, creator of the Good Conversations podcast at De Correspondent, is recording a podcast in Theater aan het Spui in The Hague. In his Good Coversations podcast, Lex talks politics, arts, journalism and science, with a wide range of guests who have an exceptional and often unknown story.…

Every year Leiden University celebrates the lifting of the siege of 1574, with the 3 October University. This year the event will be held on the 4th of October between 11 am and 1 pm. Visit the tent in the city centre of Leiden, to hear three of our scientists talk about their research on the theme…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Anthropologist Marieke Slootman received the NSV Dissertation Prize 2015 for her dissertation on ethnic identification among Moroccan and Turkish Dutch.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

What does it mean to be in a Dutch prison? What is true about the prejudices about being in jail? Criminologist Marieke Liem has released a podcast on Dutch national broadcaster NPO Radio 1: Hotel met tralies.

Marieke Liem is an Associate Professor at the Institute for Security and Global Affairs of Leiden University in The Hague. She was interviewed by local Leiden radio programme ‘Sleutelstad’ about her research into murder cases in the Netherlands.

As part Leiden University's interdisciplinary programme Social Resilience and Security, dr. Marieke Liem has been appointed Professor Security and Interventions effective 1 January 2020.

On 1 November 2018, Marieke Bloembergen was appointed Professor of Archival and Postcolonial Studies at the Institute for History.

On Monday 9 September, police officer Wendell C. (Dordrecht) shot and killed his two children and himself. The mother was also shot and died later that night in the hospital. Marieke Liem, Associate Professor at the Institute of Security and Global Affairs (ISGA) spoke with Dutch news website ‘BN DeStem’…

A mother who is far from the romantic ideal image of the mother as we know is the murderous mother. Genevieve Lhermitte, the mother who killed her 5 children, or the neurosurgeon who killed her 14-year-old daughter whose trial recently ended are examples of shocking stories. It goes against every thought…

As of 1 September, Jeroen van Zon started as professor by special appointment in Quantitative Developmental Biology at the Institute of Biology Leiden (IBL). Van Zon is also group leader of Quantitative Developmental Biology at the physics research institute AMOLF. Three questions about his new role…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

In this thesis we will explore the use of fuzzy systems theory for applications in bioinformatics.

FAIRDOM consortium is an open initiative of various partners including funding programmes, large-consortia, institutes, small groups as well as individuals.

As a humanities researcher, it is not always easy to explain to other people why what you do is important. It is easy for people to see why searching a cure for cancer matters, but it is a bit harder to make clear why it is also important to study language, culture, and history. One of the things that…

The magazine New Scientist selected 25 nominees from candidates proposed by all Dutch and Belgian universities for the New Scientist Science talent 2015 election. One of these nominees is dr. Marieke Liem, who works at the Centre for Terrorism & Counterterrorism.

Each year, around forty women in the Netherlands lose their lives, most often at the hands of a (former) partner or family member. Judges, lawyers and survivors now turn directly to Professor Marieke Liem for expertise. For her, this is telling: ‘The time has come for greater knowledge and a coordinated…

Prof. Dr. Marieke Adriaanse has been appointed as strategic representative and new member of the steering committee of the Healthy Society Programme. This programme is a collaboration between Leiden University, Delft University of Technology, Erasmus University, Medical Delta, and the Province of South…

In Belgium Radio 1, Marieke Liem (professor of Violence and Interventions) gives a scientific perspective on serial killers and explains the typical Hollywood image of serial killers is not in line with reality.

In Dutch magazine Elsevier, Marieke Liem explains the issues with using the term ‘troubled person‘ in reports on homocide.

Marieke Liem wrote a contribution for DJIzien, a magazine published by the Dutch Custodial Institutions Agency (Ministry of Justice and Security), about her meetings with long-term prisoners. ‘For my research on long-term prisoners I made numerous visits to Dutch prisons. During these visits, I came…

On Wednesday 11 December 2019, Marieke Liem, Associate Professor, appeared as a guest on the NPO Radio 1 podcast. The central topic of the podcast was risk perception among the Dutch population.

Roel Wouters (24), a biology student at Leiden University, is a finalist in the election for UN youth delegate for Biodiversity and Food. The digital polls open for a week on Friday 22 October. Under-30s can vote for Roel at www.stemroel.nl.

On Friday 9 December, Renate van der Zee and professor Marieke Liem held a lecture on 'Visible and invisible violence against women' at the Campus The Hague.

Marieke Liem, professor at ISGA, discusses how the number of drug-related murders has not decreased in the last years

Marieke Liem, Associate Professor at the Institute of Security and Global Affairs (ISGA), has been interviewed by Trouw about the opinion of the Dutch concerning the threat assessment:

Paul Brakefield, Professor of Evolutionary Biology at the Institute of Biology in Leiden (IBL) has been awarded an ERC Advanced Grant for his research. He will receive 2.5 million euro to develop his research programme over a period of five years.