How can the Safe and Sustainable by Design (SSbD) framework developed in the SSbD4CheM project facilitate the creation of safer and more sustainable chemicals and materials across various industries?

Key publications of the Quantitative Clinical Pharmacology group

In the Research in Bio-Pharmaceutical Sciences specialisation you will perform research on various topics in the area of Drug Discovery and Development. The programme offers a high level of flexibility and can be tailored to your scientific interests. The major research project is hosted by the Leiden…

The two-years MSc programme spans the entire spectrum of Analytical BioSciences, Biopharmaceutics, Drug Delivery Technology, Medicinal Chemistry, Pharmacology and Toxicology.

Ad IJzerman was elected Highly Cited Researcher in the 2019 Web of Science mapping of research achievements. As defined by the Web of Science team at Thomson Reuters “highly cited researchers are among those who have demonstrated significant and broad influence reflected in their publication of multiple…

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

The list of highly Cited Researchers identifies the world’s most influential contemporary researchers across 21 scientific fields. Prof. dr. W. Jiskoot is cited one out of three in the field of Pharmacology & Toxicology in the Netherlands, and as one of four of all categories in Leiden.

Toxys, Leiden University and Leiden University Medical Center have agreed immediately to commercialise and also develop further the ToxProfiler technology invented at the two institutions. ToxProfiler allows for rapid toxicity hazard identification of novel and existing drugs, chemicals, and other substances.…

Methods of treatment for chronic illnesses are limited. Doctors and researchers at Leiden University Medical Center (LUMC) and Leiden University are working on new therapies as an alternative for organ transplants. The goal is to cure the illnesses by restoring organs to their original function. Stem…

LED3 is the combined effort of three excellent institutes of Leiden University. Through joined hands, we are able to give rise to a more effective early drug discovery pipeline. Let us briefly introduce the three institutes.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Mrs. Dr. Constance (Stans) Eikelenboom passed away on Sunday, March 12th, at the age of 95. She was the founder of the 'Stans Award', a prize which every year has been given to the best student article of the Institute of Environmental Sciences (CML).

From the Republic of Moldova to Italy and from Indonesia to Greece, students from all over the world participated in the Bio-Pharmaceutical Science Summer School 2017. The students got a comprehensive overview of the education and research performed within the LACDR. ‘I am very happy to be here,’ says…

Venture capital investors Zeeuws Investerings Fonds and Participatiemaatschapij Oost Nederland have joined forces with national and regional partners to fund development and sales of MIMETAS’ unique 3D disease- and tissue modelling technologies.

It's now possible to measure how many plastic particles there are in our food. Chinese scientists and Leiden professor Willie Peijnenburg applied their new method to lettuce and wheat. Their results were published January 20 in Nature Nanotechnology.

Italian nurse Daniela Poggiali was arrested and convicted of murdering two hospital patients in 2014. Her case attracted the attention of Leiden statistician Richard Gill. After his investigation, together with an Italian colleague, Poggiali was acquitted last autumn. Together with fellow statisticians,…

No, this isn’t about a Star Wars Alliance that wants to suppress The Resistance. Rather, the EPIC Alliance brings together scientific experts from seven countries to address the growing threat of antibiotic resistance. Leiden professor Nathaniel Martin is part of the 11-member consortium.

There are many complex links in the chain that provides patients with new drugs: from fundamental science, to clinical tests, to production. The entire chain can be found in Leiden. Leiden University, the Leiden University Medical Center (LUMC) and the businesses at the Leiden Bio Science Park (LBSP)…

How do societies move forward with sustainable, effective and efficient management of Earth's water resources?

Students searched for MSc Internships under the following topics: 1. Understanding temporal variability in functional biodiversity and 2. Characterization of engineered nanoparticles in aquatic organisms: Gold nanoparticles and carbon nanotubes

From filtering UV light in sun cream to preventing perspiration odour in socks and sterilising fridges and washing machines. The use of nanoparticles in products is increasing. But what is the impact of these miniscule particles on the environment?

Seventeen Leiden University scientists appear on the 2019 Highly Cited Researchers list, which was announced on 19 November by Clarivate Analytics.

Martijn Manson became programme director for the Master’s in Pharmacy this month. He is a pharmacist as well as a lecturer and researcher at the LACDR (Leiden Academic Centre for Drug Research). ‘LUMC and LACDR share the responsibility for training the pharmacists of the future.’

The Minister of Education, Culture and Science has approved the application for the master’s programme in Pharmacy in Leiden. This is an important step on the road to a new master’s programme.

The large-scale project NanoInformatics will assess the risks associated with nanoparticles. The project will be funded by the EU with 6.8 million euros and was launched at the beginning of this year. Three scientists from Leiden are involved. 'For the first time, this project combines the various experts…

How do organs work in the body, and how can we create mini-organs to study diseases and test new medicines? That’s the idea behind organ-on-a-chip technology. During his PhD, Flavio Bonanini worked on developing the best possible mini-livers. ‘Make them as simple as possible, and as complex as neede…

How do you count the nanoplastics in your body? Leiden researchers published a method in Nature Protocols today that should make this easier. Important for both environmental and medicine research.

On the brand-new Leiden Teachers Blog, Leiden teachers share their experiences with educational innovation. They show colleagues, students, and everyone else who is interested the different facets of creating university education.

Nanomaterials can pass much further along the food chain than was previously thought. The particles can change shape and size in each organism, enabling them to pass on to the next one in the chain. Researchers from the Institute of Environmental Sciences discovered this accidentally when using a novel…

To what extent do nanoparticles accumulate in plants and animals, and what properties of the particles play a part in this? Willie Peijnenburg, professor of Environmental toxicology and biodiversity was awarded a Marie Curie grant to conduct research on the environmental effects of nanoparticles.

Ewa Snaar-Jagalska, Shuning He and colleagues from IBL, LION and LACDR reported on a new zebrafish study to understand micrometastasis of human cancer cells. They discovered a novel role for neutrophils in assisting metastasis formation, which provides critical insights for anti-cancer therapies.

The ‘Stans Prize 2017' (for the best thesis, report or article produced by a CML student) has been awarded to Davide De Mauro. Other CML prizes were awarded to Jeroen Guinee, Reinout Heijungs, Martina Vijver, Willie Peijnenburg en Kevin Groen

Micro- and nanoplastics cause stress to crops such as lettuce and carrots, PhD candidate Laura Julia Zantis found. This can lead to reduced growth and a lower nutritional value. Biodegradable plastics have this effect too, likely because of chemicals they release during degradation.

One of the holy grails of drug research is to be able to assess the safety of chemicals and pharmaceuticals without using laboratory animals. Researchers from Leiden University, among others, now receive a grant from the National Science Agenda to pursue that goal.

PhD candidate Agnes van Steen researched the history of the Leiden women’s rights movement (1860-1990) and found that the university produced many feminists.

Overview of all dissertations published by PhD candidates from CML.

Many of our staff and students have won prizes over the past year. Others have been awarded a subsidy, or, because of their eminence in their field, they have been appointed member of an academic society or have taken on a position in the community. Reasons enough to be proud of them and to include…

Over the past year, many of our staff and students have won prizes, been awarded a substantial grant or been appointed to an academic association or a position in public life. All of these are good reasons to include them in our 2019 Hall of Fame. We are proud of them all.