PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands

Biology consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

The Biodiversity and Sustainability consists of 120 European Credit Transfer System (EC) points and includes a theoretical part (30-60 EC) and and one or more research projects (60-90 EC).

The specialisation consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

The specialisation consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30-60 EC) and and one or more research projects (60-90 EC).

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

On this page the programme and sessions can be found.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

The INTERACT project strive to unlock the enormous biotechnological potential of microbes, leading to sustainable crop productions systems.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

The goal of hit discovery is to identify suitable chemical starting points to modulate a drug target. A hit can be, a.o., a small molecule, a protein or mRNA. Hit identification is performed via rational design, genome mining, (targeted) library screening, or in silico approaches.

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…

The organisation of the Platform for Postcolonial Readings is a collaboration of main organisers and occasional guest organisers.

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Supervisor: P.J.J. Hooykaas

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Where did species survive the cold cycles of the current Ice Age?

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The Altai region has yielded a cluster of Middle and Upper Paleolithic stratified sites that have been recently excavated using a multidisciplinary approach.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The master’s specialisation Evolutionary Biology at Leiden University investigates biology at all levels. The specialisation includes genomics, functional developmental genetics, paleobiology, behavioral biology and evolutionary ecology.

Key publications of the Analytical BioSciences and Metabolomics group

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Using EcoFab 2.0 devices and omics services at JGI, we will examine a plant growth promoting microbial community during interaction with different plant species.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Meet the ABPP2027 organisers

Early diagnosis, new treatments, and personalised care: all of these are possible if we can better unlock the wealth of information hidden in health data. Unfortunately, this data is often poorly organised, difficult to access, and not interoperable. The new international Leiden Institute for FAIR and…

Institute of Political Science

The Faculty of Social and Behavioural Sciences (FSW) offers an inspiring and competitive, international working and learning environment to around 1,025 staff and around 7,000 students from home and abroad on 13 bachelor's, master's and research master's programmes.

The programme group Learning and Behaviour Problems in Education is one of the six programme groups within the department of Child and Education Studies at Leiden University.

Various companies in the plant biotech industry will test a recent Leiden discovery in their crops. The ‘Pol Theta’ technology is developed in Leiden and makes it possible to reduce undesired side effects during genome engineering of plants.

LUXs unites statisticians from all over the university, who are all members of their own faculty. LUXs does not have its own organisational units, but it is coordinated by a Steering Committee.

The Institute of Education and Child Studies is part of the Faculty of Social and Behavioural Sciences at Leiden University. The institute is governed by an Institute Board under the direction of a rotating chairman, i.e. the Scientific Director and an Director of Studies. The Institute Board is…

The Executive Board and the Board of Education of the Institute of Psychology are responsible for the organisation. A number of committees offer specialised knowlegde, such as the Research Ethics Committee. Students have a say in programme committees.