Promotor: Prof.dr. B. van de Water, Co-promotor: E.H.J. Danen

Microbial Sciences' contribution to the Host-Microbe Interactions research theme is to investigate how beneficial or disease-causing microbes associate and interact with their host.

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

PhD at the Natural Product Laboratory, Institute of Biology, Leiden University - the Netherlands

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

Biology consists of 120 European Credit Transfer System (EC) points and includes courses and electives (30 - 60 EC) and and one or more research projects (60 - 90 EC).

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

PhD defence

On this page the programme and sessions can be found.

Early diagnosis, new treatments, and personalised care: all of these are possible if we can better unlock the wealth of information hidden in health data. Unfortunately, this data is often poorly organised, difficult to access, and not interoperable. The new international Leiden Institute for FAIR and…

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

The mission of the Plant Sciences cluster is to contribute to the sustainable production of high-quality crops, flowers and high-value bio-based products, and to contribute to the maintenance and restoration of biodiversity in natural ecosystems. This is realised by generating fundamental knowledge…

The INTERACT project strive to unlock the enormous biotechnological potential of microbes, leading to sustainable crop productions systems.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Supervisor: P.J.J. Hooykaas

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Where did species survive the cold cycles of the current Ice Age?

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

In human cells, a meter-long DNA is condensed inside a micrometer-sized cell nucleus. Simultaneously, the genetic code must remain accessible for its replication and transcription to functional proteins.

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

The Altai region has yielded a cluster of Middle and Upper Paleolithic stratified sites that have been recently excavated using a multidisciplinary approach.

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Key publications of the Analytical BioSciences and Metabolomics group

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

The master’s specialisation Evolutionary Biology at Leiden University investigates biology at all levels. The specialisation includes genomics, functional developmental genetics, paleobiology, behavioral biology and evolutionary ecology.

PhD defence

PhD defence

Key research articles, reviews and books of the Chromatin group.

Leiden University offers you several services related to career orientation and job application skills.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Uncover novel antimicrobials with prospective health benefits for sea turtles.

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

On this page the programme and sessions can be found. The programme will be updated regularly.

The article investigates the origins of Indo-European languages in Asia by 65 coupling ancient genomics to archaeology and linguistics.

Microbial Sciences' contribution to the Bioactive Molecules research theme is to discover new bioactive molecules and enzymes and unravel their mechanisms of action, regulatory networks, and the (bio)synthetic pathways required for their production.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets

The master's specialisation Molecular, Cellular and Organismal Biology at Leiden University examines the molecular mechanisms underlying health and disease and how cells and organisms adapt to environmental factors.

The main purpose of DNAmarkerpoint is to better understand the ecology, evolution and biodiversity through the study of ancient- and modern DNA.