This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

Our group operates at the cross-roads of different disciplines: molecular and cellular microbiology, biochemistry, structural biology and biophysics. The group harbors expertise in a multitude of molecular and cellular approaches including:

Promotores: Prof.dr. M. Franx & Prof.dr. P.G. van Dokkum (Yale University)

This thesis advances automata learning, a key area in computer science, with applications in software verification, biological analysis, and autonomous technologies. It explores three main themes: first, it introduces a passive learning algorithm for generating compact probabilistic models from positive…

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

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The origin and evolution of galaxies are closely linked to many different physical phenomena.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

The research groups within the biological, soft and complex systems research area study the physics of a broad range of biological and soft materials. This spans both experimental and theoretical research.

A plasma is an ionized gas with very low electrical resistivity. As such, magnetic field lines are 'frozen in' and move with the fluid. Magnetic field lines that are linked, knotted and tangled, cannot be undone by the fluid motions.

This is the physics summer school of Leiden University. It is part of the Leiden Institute of Physics (LION). The summer school is intended for Bachelor (BSc) students in physics. It covers topics from quantum matter and optics, to biological & soft matter physics and cosmology and theoretical physics.…

This dissertation focuses on investigating the public communication around quantum science and technology that may affect public engagement.

PhD defence

Check your application deadlines here. Take note: Not all programmes have the same deadlines; always check the individual programme descriptions for application deadlines.

eLaw – Center for Law and Digital Technologies offers educational programs at Pre-University, Bachelor, Master’s, Advanced Master’s, and postgraduate level in the field of law, technology, and society.

Human cells are protecting their proteins from unfolding and aggregating. That's what biophysicist Alireza Mashaghi and his team discovered after seven years of in-depth research into the folding mechanisms of proteins. With an unprecedented approach, the team was able to study the folding of a single…

The Joan van der Waals colloquium is an ongoing bi-weekly lecture series.

Physicists at the Leiden Institute of Physics (LION) conduct fundamental research into physical phenomena. They are inspired by curiosity and the desire to know more about the world in which we live. This research has always paved the way for new practical applications. These are something that the…

Archaeometric analysis of glazed pottery assemblages from the Early Byzantine to the Early Modern periods in the Aegean.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Surface plasmons (SPs) are surface waves at the interface between a dielectric and a good metal, and are formed by the interaction between light and the free electrons at the metal-dielectric interface. They provide strong field confinement for optical fields, opening new possibilities for enhanced…

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For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Research in the Jawerth lab focuses on using principles from soft condensed matter physics to understand important biological materials.

Promotor: T. Schmidt

Develop EPR instrumentation and methodology to investigate intrinsically disordered proteins (IDPs).

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotores: F.H. van Lunteren, F.P. Israel

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

On this page you can find the current vacancies at the Van der Molen research group.

To study how planetary systems come into existence we study much younger systems still in formation.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

This PhD-research is conducted to test the hypothesis that Gutenberg and consorts developed a standardised and even unitised system for the production of textura type, and that this system was extrapolated for the production of roman type in Renaissance Italy.

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

This PhD-thesis presents a study on micron-sized particles, so-called colloids. By controlling the chemical and physical properties of these particles, such as the interparticle interaction and the particles’ shape, colloids can act as building blocks that self-assembly into larger structures.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

A large diversity of exoplanetary systems has been found, but it is still unclear what drives this diversity.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.