MHC class I and MHC class II molecules present peptides to the immune system to drive proper T cell responses. Pharmacological modulation of T-cell responses can offer treatment options for a range of immune-related diseases.

Comparing gazes between Turin and other cities in the global north.

Lecture

Lifelong learning | “Even though we were spread across five continents, there was a strong sense of connection.”

The promising early results of an international study have shown that insulin-producing cells grown from stem cells can cure the disease. The new Cure One LUMC research centre aims to accelerate this breakthrough.

Conference

Repairing organs, tissues and cells to fight chronic diseases.

Researchers Wim van Noort, Sandra Groeneveld, Marieke van der Hoek, Jelmer Schalk en Joris van der Voet published a book on public organizations.

Assessing the feasibility and legitimacy of the current model of global tax governance and the role of the OECD and EU in international tax law-making.

A new therapy for the serious Graft-versus-Host disease

In this article, Tom Buitelaar proposes a systematic framework for analyzing the impact of individual characteristics of peacekeeping leaders on the behaviour of field-level personnel in UN peacekeeping operations.

Zeger van der Wal, Professor by special appointment Ien Dales Chair at Leiden University, and Mehmet Akif Demircioglu, Assistant Professor ar the Lee Kuan Yen School of Public Policy, researched the effects of ethical culture and ethical leadership on realized innovation.

On October 19, the Center for Law and Digital Technologies of Leiden University (eLaw) organized the first annual Hans Franken lecture. The lecture;

This subproject examines how memories of flight and persecution shaped new social and religious identities in the Netherlands.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

An exploration across thirteen essays by critics, translators and creative writers on the modern-day afterlives of Old English, delving into how it has been transplanted and recreated in the twentieth and twenty-first centuries.

The overlapping of intergovernmental organizations sharing Member States is one of the key challenges for achieving effective regional integration.

Buitelaar argues that IOs micro-level discourse adapts imperfectly to macro-level changes, balancing adaptation to pressures with commitment to values.

For the first time, astronomers have detected the presence of complex organic molecules, the building blocks of life, in a protoplanetary disc surrounding a young star. The discovery reaffirms that the conditions that spawned the Earth and Sun are not unique in the Universe. The results are published…

As part of the events to mark the 100th anniversary of the International Labour Organization, the Department of Labour Law of Leiden University has organized a film evening together with Kijkhuis cinema in Leiden.

PhD defence

PhD defence

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The Organ Art of the first female German concert organist and Bremen Cathedral organist and

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

For the third consecutive year, LACDR organized the international symposium on topology, Circuit Topology III, on November 29, 2023. The event aimed to bring together experts from diverse fields, including mathematics, computer science, physics, chemistry, and biomedical sciences, to discuss cutting-edge…

This year, the International Institute of Air and Space Law (IIASL) attended the first days of the 41st Assembly of the International Civil Aviation Organization (ICAO).

On Tuesday 11 February, the European Data Protection Supervisor, Mr. Wojciech Wiewiórowski, visited eLaw, - center for Law and Digital Technologies at Leiden Law School to give a lecture on facial recognition systems and data protection in Europe.

The postdoc received the 2020 Thesis Prize for her PhD research on the role of the EU Member States in regulating and remedying corporate human rights violations.

Carbohydrates, alongside proteins and nucleic acids, constitute a crucial and versatile family of biomolecules present in all life forms. They manifest as monosaccharides, oligosaccharides, and polysaccharides, covalently bonded to proteins and fats. Carbohydrates are integral to plant and arthropod…

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

Promotor: G.A. van der Marel, Co-promotor: J.D.C. Codée

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Friso Selten recently started a PhD position that is part of the SAILS program. This PhD project is a collaboration between FGGA, LIACS, and eLaw, and is supervised by Bram Klievink (FGGA), Joost Broekens (LIACS), and Francien Deschene (eLaw). In the project Friso will investigate the influence of artificial…

Since 1919 the International Labour Organization (ILO) has been promoting the rights of workers worldwide. On 7 February, Leiden University hosted the symposium celebrating the 100-year anniversary of the foundation of the ILO. Leiden emeritus professor of International Labour Law Paul van der Heijden…

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Promotor: Prof.dr. G.P. van Wezel

Globally, the number of deaths from infections is on the rise as more bacteria become resistant to antibiotics. New classes are desperately needed. A promising resistance inhibitor is now being developed by the research group of Nathaniel Martin, Professor of Biological Chemistry. Inaugural speech on…

The Leiden University Medical Center (LUMC), the Danstem Institute from the University of Copenhagen and the Murdoch Children’s Research Institute in Melbourne have received 300m euros from the Novo Nordisk foundation. The aim of this new international consortium is to bring stem-cell based therapies…

This workshop intends to bring together early-career researchers from different fields working on international organizations, to discuss methodological challenges together with peers and established scholars. A combination of a master class, keynote lectures, and roundtable discussions aims at providing…

What are the biological effects of Chinese herbal medicine in regulation of cancer cell metastasis?