The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

The neolithization of the southern Netherlands in an antropological and geographical perspective

The research contained in this dissertation explores the origins of fire making in prehistory, focusing primarily on the fire use practices and fire production capacities of Neandertals.

This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.

The subject of this thesis is Alverata, a twenty-first-century typeface whose design was inspired by the shapes of Romanesque capitals such as those found in inscriptions of the eleventh and twelfth centuries.

In this theme you will be supplied with a firm background in the core of current computational linguistics and a solid comprehension of its neighboring fields.

PhD defence

PhD defence

Two excellent young chemists, Jeroen Codée and Sander van Kasteren, have received an ECHO grant for €260,000 from the Netherlands Organisation for Scientific Research (NWO). This funding will allow them to begin their research projects.

Target selectivity is an important aspect of any drug molecule, and certainly a parameter to be optimized. That is not trivial for a number of reasons. First of all hundreds of drug targets (receptors, enzymes, ion channels) exist, and no single lab in the world has assays for all of them.

While colloidal aggregates are often undesirable due to their random shapes, we exploit them as a starting point to synthesize patchy particles.

The chemical industry must continue to innovate for a more sustainable, healthier society. The reseachers from the Leiden Institute of Chemistry (LIC) contribute by applying their knowledge to themes such as sustainability, energy and health.

In modern information systems, a large number of different components are often active simultaneously. This phenomenon - known as concurrency - underlies not only the functioning of computer systems but of any system in which many processes take place at the same time.

Humanity stands at a pivotal juncture, facing the dual challenge of environmental sustainability and rapid population growth, projected to exceed 11 billion by century’s end.

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

What kinds of vocal music were not typically transmitted in written musical notation? Can specific ‘lost’ song forms - siciliane, giustiniane, le Grechesche, gli stili “regionali“ nel canto del quattrocento - be more precisely identified than they have been until now, both in musicological research…

Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Pottery traditions and social interaction in the earliest Neolithic of the Lower Rhine Area

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

The sites of Norman Estata, Anse des Pères and Hope Estate with a contribution to the 'La Hueca problem'

Prince, Pen, and Sword offers a synoptic interpretation of rulers and elites in Eurasia from the fourteenth to the eighteenth century. Four core chapters zoom in on the tensions and connections at court, on the nexus between rulers and religious authority, on the status, function, and self-perceptions…

Promotores: Prof.dr. A.G.G.M. Tielens & Prof.dr. L. Kaper (UvA)

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

What are the functions of the endocannabinoid system?

The goal of this study is to systematically investigate how intonation (speech melody) is conveyed in whispered speech.

Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…

On 8 June, Wanlu Zhang defended the thesis 'Protection of aviation security through the establishment of prohibited airspace'. The doctoral research was supervised by Steven Truxal and Robert Heinsch.

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

This study stresses the importance of investigating vitamin D deficiency in every community to better understand the deteriorating effect that sociocultural practices may have had on health.

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Natural vanilla flavor is one of the most important in the world. However, the cost of this flavor is expensive. Production of this flavor by alternative methods, could reduce the cost.

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

This book is about the archaeology of indigenous peoples who thrived across the Caribbean, the Guianas, and the Lower Amazon basin just before the European invasion, and who also remained central to the early history of conquest and colonization.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

This is an Erasmus+ International Credit Mobility project of the Faculty of Sciences with one partner in Ukraine.

At ACPA, the collaboration between Leiden University and the University of the Arts The Hague, artistry and academia meet at the highest level.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

Speech Prosody 2024 will hold an industry panel on Prosody in Tech.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Promotor: A. Kros

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

In the emerging field of small-molecule RNA targeting, there is a growing demand for new high-throughput screening methods.