Scientific research at the molecular level on a collection of medieval skeletons from Norton Priory in Cheshire, United Kingdom, could help rewrite history after revealing they were affected by an unusual ancient form of the bone disorder, Paget’s disease. Osteoarchaeologist Carla Burrell, attached…

With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…

Large numbers of children all over the world face significant health risks, such as infectious and chronic diseases, malnutrition, injuries and the consequences of natural disasters, protracted armed conflicts and poverty.

Alzheimer’s disease and cancer are two examples of diseases that are related to malfunctioning cellular patterns. The examination of cell tissue, however, takes a lot of time and generates a lot of data. To make the analysis of data easier, Antonios Somarakis of the Data Science Research Programme (DSRP)…

In order to better understand the course of Alzheimer’s disease, Frédérique Kok believes that a strategic and structured approach is needed: the Mastermind research approach. With her LUF grant, Kok wants to generate high-quality data to build a mathematical model that can recognize the onset of the…

This thesis describes the design and synthesis of novel small molecules based on sulfur-containing heterocycles for the inhibition of glycosidases and glycosyltransferases related to Fabry and Pompe disease.

It might be possible to prevent atherosclerosis by changing the appearance of macrophages, cells of the immune system that for example digest foreign substances. In her PhD dissertation, Baoyan Ren examined several ways to do so.

Researchers at Leiden University have made a breakthrough in the study of the hereditary Pompe disease. Together with colleagues in York, they have developed a molecule that binds to the enzyme that is key to the progress of the disease. The findings have been published in ACS Central Science.

We use zebrafish as a model organism to study human development and disease as well as animal welfare and environmental impact.

An overview of the research at the Biologics Formulation group

Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…

Scientific Director of the Leiden Academic Centre for Drug Research (LACDR) Hubertus Irth: ‘We test substances and look for new concepts for treating disease.’

‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…

The interdisciplinary two-year Master Population Health Management will train you to tackle the challenges and contribute to a more integrated healthcare system.

If you imagine in advance that something is not going to hurt, this could mean you experience less pain. This discovery was made by health psychologist Kaya Peerdeman during her PhD research on the placebo effect. PhD defence 7 February.

Cardiovascular syndromes are the major cause of death in Western societies.

One and a half hectares of polder, a large volume of water, and a group of curious researchers from various universities and scientific backgrounds led by ecologist Maarten Schrama. These are the ingredients needed to answer the question: how do water retention areas affect nature, animals, and our…

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Biophysicist Alireza Mashaghi and his collaborators are taking up the fight against muscular dystrophy: genetic disorders that cause muscle weakness. They want to inhibit the clumping of proteins that results in toxic aggregates. For this, the team receives 550,000 euros from Health Holland. The team…

This article examines how the threat of terrorism has been addressed at the policy level through an analysis of a specific case in Mali.

The AT-Hook Nuclear Localized 15 (AHL15) gene belongs to a plant-specific gene family of DNA-binding proteins. Overexpression of AHL15 in Arabidopsis thaliana delays developmental phase transitions whereas its loss of function causes a slight acceleration.

If you wish to know exactly what is going on in a healthy or sick human body, and at various levels such as molecule, cell, tissue, organ, larger systems and a person as a whole? Do you wish to learn how to do research which contributes to diagnoses, treatment and prevention of diseases? Then the bachelor…

The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.

Two bacterial species team up inside the plant root system to rescue their host from fungal infection. This was discovered by a team of microbiologists and bioinformaticians from the Netherlands Institute of Ecology, Wageningen University, and the Institute of Biology Leiden. They also identified the…

Organs and tissues grown in the lab may in the future be able to cure people with organ failures. Micha Drukker, professor of Stem Cells, Developmental Biology and Technology for Innovative Drug Research, is convinced that the use of stem cells will make this possible. He will deliver his inaugural…

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

We aim to engineer streptomycetes to fully exploit their potential for natural product productions, by a rational design and evolution approach.

Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager

We are looking for students who are 16 years or older and are studying at a Dutch mbo, hbo or university. Our aim is to gain insight into the needs and perceptions of students regarding stress and burnout. In short, we aim to carefully listen to the students’ needs: how can we help you?

Are you curious about how health, behaviour and our living environment are connected? At Leiden University, you’ll explore how people grow up, age and live together in a changing world. From mental health to healthcare innovation, from lifestyle to healthcare policy: you’ll learn to understand societal…

Are you curious about how health, behaviour and our living environment are connected? At Leiden University, you’ll explore how people grow up, age and live together in a changing world. From mental health to healthcare innovation, from lifestyle to healthcare policy: you’ll learn to understand societal…

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

The research of this PhD project can be subdivided into two main disease areas: migraine and stroke. For both we will be investigating how artificial intelligence (AI) and machine learning (ML) techniques can be used to study these afflictions, their (early) detection, and their potential treatment.

As of 14 May, people from all over the world can follow a little part of our university’s education through a new Massive Open Online Course (MOOC) on Health & Health Behaviour. This MOOC provides an introduction to the field of Health Psychology.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

When mosquito eggs hatch in nutrient-rich water, the mosquitoes are larger and they can also fly further. That is the first conclusion of a study from by the Netherlands Centre for One Health (NCOH) by PhD-student Sam Boerlijst.

The financial system needs complexity theory to predict economic crises like the 2008 meltdown. An international team of scientists, including Leiden physicist Diego Garlaschelli, state this in a paper published in Science on February 19th.

How can we as a society prevent suicide? According to Professor of Suicide Prevention Renske Gilissen, a better understanding and targeted action could help save lives.

In July, 2018, the Institute of Biology Leiden hosted the 11th conference of the Zebrafish Disease Models Society (ZDMS), an international association dedicated to the advancement of basic and clinical research using zebrafish disease models. More than 350 researchers from all over the world gathered…

A study into the impact of historical socioeconomic changes on the respiratory health of past Dutch populations (ca. 470-1850 CE)

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health, writes PhD candidate Joachim Nieuwland. PhD defence on 13 May.

Professor by Special Appointment of Clinical Neuropharmacology Geert Jan Groeneveld will deliver his inaugural lecture entitled ‘The importance of the biomarker’ on 11 March 2022. According to him, new genetic knowledge will revolutionise drug research.

Preventing terrorism before it happens seems like an idea no one would disagree to. But is it possible? How do counter-radicalisation policies look like? And are there dangers of unintended consequences? Francesco Ragazzi, Assistant Professor at Leiden University’s Institute of Political Science, has…

The Netherlands has a long history of mosquito-borne diseases, particularly malaria, until 1970 when it was declared malaria-free.

Can drugs that target host signaling pathways be used to eradicate antibiotic-resistant bacteria?

Five talks will be given during the Leiden Science Family Day: two children's lectures and three lectures for adults. Will you be there ?