The research of the Biotherapeutic Delivery group led by Joachim Van Guyse focuses on developing novel polymer-based formulations for therapeutic nucleic acid and protein delivery. The research revolves around developing structure-activity relationships between the chemical structure of polymers, the…

Hydrogen peroxide (H2O2) generation via electrochemical oxygen reduction is a sustainable production method for this bulk chemical. However, the selectivity of molecular catalysts for electrochemical H2O2 generation has hardly been investigated in a systematic manner, and it is unknown if their stability…

In this thesis, topics relating to the optimization of high-throughput pipelines used for imaging are discussed. In particular, different levels of implementation, i.e., conceptual, software, and hardware, are discussed and the thesis outlines how advances on each level need to be made to make gains…

Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.

This study aims to explore the use of a behavioral-design-based approach in simulating patient flow through EMTs. It provides a dynamic behavioral simulation model to assess the interactions between patients, staff members, and the related dynamic movements/interactions with the health care facility,…

Plastics are an intrinsic part of our society. Annually, 400Mt of plastics are produced of which roughly 40% is discarded within a year.

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

Exploring the integration of AI and quantum computing, this study adapts Knowledge Representation and Reasoning (KRR) to enhance quantum circuit simulation and optimization.

Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.

We are doing all we can to save energy at the university. Find out how you as a member of staff or student can do about energy and help reduce CO2 emissions.

Many important topics in computer science, such as the correctness of software, the efficiency of algorithms and the modeling of complicated systems, depend on sound theoretical underpinnings. In the Theory group, we study these fundamental building blocks and develop verification methods to prove system…

Development & demonstration of low environmental impact innovation and optimization practices in pharma production.

Twenty years from now, the world population is estimated to be around 9 billion people (now 8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this population will result in an enormous increase in the demand for food, consumables, water…

The LACDR represents the core of bio-pharmaceutical research at Leiden University, and we interact closely with our partners:

An overview of the research at the Biologics Formulation group

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

Joost Batenburg is a mathematician and computer scientist who works to build bridges to other disciplines. He hopes to bring intelligent software to fields where it can make a difference. Conversely, he also seeks connections to the disciplines that are needed to make AI a success.

The research programme Probability Theory focuses on probability theory and on operations research.

Learning from nature and utilizing microbial biodiversity to identify and characterize enzymes for degradation and upcycling of plastics and other polymeric materials.

We find ourselves in an era of transition, not just towards a more computing- and data-driven society but also away from unsustainable fossil fuels as an energy source.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…

Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

During the development of the Humanities Campus, as many 'green choices' as possibile are being made. This concerns the buildings as well as the surrounding area. Making the campus more sustainable is measured using the BREEAM.NL method.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

On 15 February 2024, Alexandros Sarris defended the thesis 'International Law and Governance of the Arctic in an Era of Climate Change'. The doctoral research was supervised by Nico Schrijver and Freya Baetens.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

Intelligence scholars have been struggling to find the conditions under which international intelligence cooperation occurs. Most focus on transactional motives and guaranteed returns, the so called ‘Quid pro Quo’. At the same time, trust is often mentioned as one of the foremost conditions, yet it…

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Key publications of the Biotherapeutic Delivery group

Just as in phase 1, phase 2 of the Gorlaeus Building will focus on sustainable building.

Why do many medical institutions struggle to use AI in their clinical practice? What are the essential steps for and before an effective implementation of AI in radiology workflow? How can AI implementation trigger enduring improvements in the clinical process? The book shows how change management is…

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Promotor: G.P. van Wezel

The potential of liposomal cancer vaccines

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

This dissertation presents new cryptographic protocols, which can be divided into two families.

The PML specialisation prepares you with knowledge and understanding of the key concepts and theories of management, leadership, decision-making and policy implementation in national and international government organizations.

Promotor: J. Zaanen

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

This book provides the answers, presenting clear insights into the current state of affairs and exploring future prospects.