Promotor: J.W.M. Frenken

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

Ehrenfestgarage, Emmy Noetherweg , 2333BK, Leiden

Bacteria have the ability to alter their morphology in order to adapt to changing environments.

Our previous meta-analysis (Swart et al., 2019) had shown that feedback targeting text comprehension given when students perform a reading task positively influences learning from text. So far, differences in the effects of feedback were explained by design features, such as the timing and richness…

On Tuesday 3 September 2024 Straton Papagianneas successfully defended a doctoral thesis and graduated.

Key publications of the Biologics Formulation group

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Archaeological heritage management is concerned with the identification, protection, management and preservation of the material remains of human activity in the past (of whatever period and in whichever region of the world) and with the interaction that this involves with all kinds of stakeholders.

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

This thesis utilises the exceptional sensitivity and resolution of LOFAR to explore the low-frequency Universe, while simultaneously advancing the telescope's capabilities to enable new scientific discovery.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

This thesis investigates a pharmacological challenge model induced by Toll-like receptor 7 (TLR7) activation, focusing on skin inflammation and its implications for early drug development.

Aviation safety is of global concern. Yet 43% of countries worldwide lack the expertise and administrative capacity to ensure effective safety oversight of the aviation activities for which they are responsible under international law.

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Promotor: Prof.dr. H.J.A. Rottgering, Co-promotor: David Sobral

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Promotor: Prof.dr. F.S. de Boer

Living together in a residential setting adds another dimension to this learning, as our students have to learn to live with others who may not share the same daily routines or standards.

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Heart failure is a major health care problem with high mortality.

Promotores: Wim Jiskoot; Ferry Ossendorp

On Thursday 11 May 2017, Qiang Yu defended his doctoral thesis ‘Market Power and Competition Law in the Software Industry’. The supervisors of the research are Professor T.R. Ottervanger and Professor S.C.G. Van den Bogaert. A brief summary of his thesis is provided below.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Hydrodesulfurization (HDS) is an ubiquitous part of oil refining that ensures that fuels are cleaned of impurities and environment release of pollutants such as SOx and NOx gasses are minimized.

Promotor: J.N. Kok, Co-promotor: M.S. Lew

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

This thesis describes the design, characterization and application of dextran based crosslinked network.

The Film Studio in Huizinga 0.13 has facilities to record professional videos for a range of educational and/or research purposes.

Combinatorial games are games for two competing players, moving in a turn-by-turn fashion, in which there is no chance nor hidden information⁠. Chess, checkers and the simpler tic tac toe are well-known examples of this class of games, as well as game of go⁠.

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

Kohei Suzuki, Assistant Professor at Institute of Public Administration, researched, together with two other authors, whether public managers with private sector experience have more core managerial values.

Within this project, PeptoMiktoStars were realized through an orthogonal protecting group strategy and should be investigated further regarding their potential as drug delivery systems in the field of drug delivery to inflamed areas in cancer, bacterial infections or autoimmune diseases.

This thesis examines enzyme domain architecture and engineering to improve the breakdown of lignocellulose and starch, abundant biopolymers crucial for sustainable biofuel and biochemical production. Carbohydrate-active enzymes (CAZymes) facilitate this degradation, but the structural complexity of…

This study examines the mutual intelligibility between all 225 pairs of 15 Chinese dialects, in two main branches, i.e., six Mandarin dialects and nine non-Mandarin (Southern) dialects.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

Courses cover a broad range of relevant subjects and provide in-depth theoretical knowledge as well as training in practical skills and advanced research tools.

Business Process Model and Notation (BPMN) has become the standard for business processes diagrams.

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

As a non-invasive genetic method, eDNA based approaches have become an important component of ecologists' and environmental managers' toolkits for biomonitoring in conservation and an increasingly important source of ecological knowledge.

When a star gets too close to a supermassive black hole, it is torn apart by strong tidal forces in a tidal disruption event (TDE).