Basketry, cordage and textiles made of plant fibers or bark are rarely preserved in the archaeological record. By means of experimental archaeology and microwear analysis, we obtain indirect evidence about this important craft.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

The chemical synthesis of inhibitors and probes targeting endo-glycosidases.

How can we effectively increase biodiversity and climate resilience in Dutch cities from an ecological, societal and governmental perspective?

Promotor: G.A. van der Marel, Co-Promotor: J.D.C. Codée

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In this project, researchers from computer science, law, psychology, and public administration research in practice how artificial intelligence (AI) can be leveraged to make decision-making in the security domain more effective, while also keeping it safe and accountable.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

The new S&RBB minor turned out to be rather popular. Together with the master applicants for the Fundamentals course, S&RBB started with 71 new students, the highest number ever.

As of February the SBB team has expanded. Simcha Jong has joined the team as a Professor and Director of Science Based Business.

Practise in the Board Room and getting start-ups through difficult times. Students of Harmen Jousma, lecturer in Science Based Business, learn about the art of doing business. Jousma is one of the three nominees for the Leiden Teaching Prize.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

PhD defence

Promotor: Prof.dr. R.M.H. Merks

Promotor: M. Ubbink, Co-promotor: G. Siegal

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

This thesis describes the synthesis, analysis of various tetrazine bearing compounds and use in bioorthogonal chemistry.

Promotores: Prof.dr. M. Danhof, Prof.dr. D.R. Stanski

PhD defence

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

Lecture

PhD defence

Lecture, Tuesday Talk

This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.

We increasingly look at international consortia to come up with scientific and technological advances that are needed to address global challenges in areas such as health, the environment and clean energy. However, organising these consortia involves unique challenges. To identify these challenges,…

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).