Through our research, we aim to enhance both scholarly understanding and practical knowledge in sustainability governance, while making meaningful contributions to the public debates on these critical issues. To achieve this goal, we embrace diversity in our research topics, methodological approaches,…

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Farming practices, food production, and the agricultural potential of the Late Bronze Age (1600-1200 BCE) Argive Plain, Greece

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Keeping our planet healthy in a just and responsible way.

In this article, published in Brill’s Encyclopedia of the Religions of the Indigenous People of South Asia Online, Erik de Maaker posed three questions. How can the persistence of the community religion, albeit marginalized, be explained? What role is left for the practices, objects, and beliefs associated…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Corrie Bakels & Hans Kamermans (eds) (2009)

Mission: The Environmental Biology department aims to increase the scientific understanding of how current and emerging anthropogenic threats affect biodiversity and ecosystem services. Through this understanding they facilitate strategic management of natural resources by addressing urgent challenges…

Irna Hofman defended her thesis on 10 January 2019.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

The book ‘Pesticides and the Environment’ gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Exploiting the Ecological Role of Natural Products as Novel Biocontrol Agents (LIPQUORUM): The central aim of LIPQUORUM is to unravel the intricate interkingdom signaling mechanisms between the Bacillus subtilis species complex and the devastating fungal pathogen Sporisorium scitamineum.

Dr. at the Department of organic chemistry, Wageningen University - the Nederlands

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon

This is a joint PhD of the Faculty of Social and Behavioral Sciences at Leiden University and the Evolutionary Ecology Group at Antwerp University.

This thesis explores how bees and hoverflies are distributed across the Dutch landscape and how ecological and landscape factors shape their occurrence.

Which plants in the Mediterranean garden were already known to the ancient Greeks and Romans, and how were they utilized?

The thesis is about how auxin and AGC kinases regulate male fertility. The main AGC kinases studied in this thesis is PDK1, PDK2 and AGC1.5, AGC1.7.

The refurbished P.J. Veth Building - the first completed sub-project in the Humanities Campus project - was officially opened in the summer of 2017. The Faculty of Humanities moved in straight away. . The building was meticulously transformed into a modern teaching building with attractive areas for…

MRFM combines the principles of magnetic resonance and atomic force microscopy.

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Hydrogen peroxide (H2O2) is an important bulk chemical that is used in various industrial processes. More than 95% of the H2O2 used in industry is made via the anthraquinone process during which a large amount of energy is going to waste.

Promotores: Prof.dr. H.J.M. de Groot, Prof.dr. J. Matysik (Universitaet Leipzig)

Ever since the FDA approved the drug bedaquiline, which interferes with the bioenergetics of Mycobacterium tuberculosis by inhibiting the activity the F0F1-ATP synthase, respiratory-chain enzymes have been an active target space for the discovery of new antibiotics. To aid in this pursuit, we aim to…

Master projects are available in

On Tuesday September 11th, the Leiden Institute of Physics (LION) organizes the third edition of its annual Science Day. Scientists from disciplines all across the physics spectrum will elaborate on their research during seventeen interactive talks. LION organizes the event to showcase the full range…

Four scientists from Leiden University have each been awarded a Starting Grant by the European Research Council (ERC). This grant, worth up to two million euros, gives researchers the opportunity to head up a research team for five years.

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

Leiden Science’s monthly dose of research inspiration from our staff, for our staff and all other curious minds.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Some species of proteins which can form liquid-like condensates, also exhibit growth into fibers (or fibrils). One particularly interesting set of such proteins are those that are associated with neurodegeneration in which the fiber growth may be related to the pathological fibrils observed in disea…

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Early time-resolved experiments by Frauenfelder on the ensemble of the kinetic rebinding of CO to myoglobin molecules resulted in a stretched exponential relaxa-tion due to a very large spread of the reaction rates of individual molecules.

The goal of target discovery is to identify and validate proteins and biological pathways that are involved in the disease process. Modulating these target proteins and pathways with small molecules, therapeutic proteins or other biomolecules (e.g. mRNA) could deliver an effective and safe drug or v…

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Promotor: J. A. Bouwstra

The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.

In this study, we evaluated the influence of supercritical carbon dioxide (scCO2) spray drying conditions, in the absence of organic solvent, on the ability to produce dry protein/trehalose formulations at 1:10 and 1:4 (w/w) ratios.

Promotor: A. Kros

In the research programme Drug Discovery & Safety, we are interested in the efficacy and safety of new drugs and novel means to decipher these aspects. Hence, we employ advanced imaging and high-throughput screening techniques next to computational approaches such as chem- and bioinformatics.

Tackling key challenges of Chemical Biology and Medicinal Chemistry to aid drug discovery is one of the focus areas of Leiden University. To this end, the Leiden Early Drug Discovery & Development network (LED3) was established by the Leiden Institute of Chemistry (LIC), the Institute of Biology Leiden…