Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

The dissociative chemisorption of a molecule on a transition metal surface represents a rate-limiting step in many heterogeneously catalyzed processes, whereby most chemicals are made. In spite of the importance of this reaction, an accurate first principles approach to modeling it does not yet exist.…

To be eligible for Chemistry at Leiden University, you must meet the following admission requirements.

Research at the Macromolecular Biochemistry group is comprised of the following research themes:

PhD defence

The current projects of the Molecular Physiology group focus on proteins of the endocannabinoid system, kinases and antibacterial targets. MSc- and BSc-students can contact Jessica van Krimpen-Kraaijenoord to apply for research internships.

How can we organise society so as to keep our planet habitable for us and for all other life forms around us? To answer this question, Leiden researchers collaborate across disciplines, from biology to data science, and from environmental economy to archaeology.

With cancer, a person’s body cells grow uncontrollably. Putting together a detailed picture of how this comes about makes it possible to develop efficient therapies. Researchers at the Leiden University Medical Centre (LUMC) and Leiden University are working together to gain a better understanding…

If you are interested in Life Science and you are looking for a programme with ample opportunities to put together your own study path, our Life Science and Technology programme is the right choice. The programme focuses on societal problems at the molecular and cellular level.

We investigate the molecular basis underlying health and disease and provide answers to existing and emerging health problems. Within this theme, we study diseases ranging from rare genetic disorders to cancer and infectious diseases. We make use of a wide variety of model systems and pursue diverse…

Leiden University College The Hague received the 'Top rated Programme' seal from the Keuzegids Universiteiten 2023 (Dutch University Guide). It is the tenth consecutive time the Liberal Arts & Sciences programme focusing on Global Challenges is awarded the honorary seal.

Is it possible to diagnose diseases using molecular switches? The new international consortium LogicLab will address this question. Leiden chemist Sylvestre Bonnet and Leiden pharmacologist Thomas Hankemeier are involved in the project. LogicLab will run for four years and will receive over 3.5 million…

Project TARGET is a research project aimed at the relation between the illegal arms trade and firearm violence. In a study conducted in seven countries, the researchers took a look at the differences and similarities. Katharina Krüsselmann and Marieke Liem took a closer look at the situation in the…

A significant percentage of children who have spent a period in youth care institutions or foster homes since 1945 received inadequate protection from physical, psychological and sexual violence. Interventions by supervisory authorities in cases involving violence were inadequate.

PhD defence

Andrew DJ Shield (History) and Ann Marie Wilson (Leiden University College) have been awarded a seed grant for their project, “Transnational Gay/Lesbian Activism since the 1960s.” Granted: €3000.

Are you interested in taking up an extra challenge during your master’s programme?

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Cancer is the leading cause of death in the Netherlands, and, with over 100 different types of cancer, it’s not a simple disease. Today, skin, breast, lung, prostate and colon cancer are the most diagnosed forms. Therefore, the discovery and development of new drugs has the ability to significantly…

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Science with University of California.

Supervisor: Natalia Ortiz Zacarías

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology. We are part of the Faculty of Science at Leiden University.

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

The Institute Board is responsible for the overall management of the institute, as well as the administration and organization of the institute’s teaching and research activities. Research and education are managed collaboratively, with strategic input from various representatives and groups, including…

Research at the BIOSYN group is comprised of the following research themes:

Research at the SBC group is comprised of the following research themes:

Are you interested in taking up an extra challenge during your master’s programme?

The studies presented in the work show the potential of the integrative use of biophysical data in defining the structural basis of protein interactions.

Lecture

Edith Schippers, Minister of Health, will be investing six million euros over the coming four years to boost research on new antibiotics. The programme will be set up by several different parties, including the Leiden Centre for Antimicrobial Research.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

The research area of this division is focused on the development of novel therapeutic modalities and novel concepts in early drug discovery, in order to better predict ligand-target interactions.

Promotor: Prof.dr. J.P. Abrahams

Cytotoxic T-cells (CTLs) are involved in the clearance of viruses and killing of tumor cells.

The CIGR brings together a diverse range of unique expertise in genome research rooted in biology, chemistry and physics. Members of the CIGR investigate genome folding and genome transactions. An important aspect is direct as well as long term relevance for medicine. The available expertise extends…

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

We showed that constitutive and inducible chemical and morphological defenses against Western flower thrips differ between tomato and chrysanthemum plants.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Through courses and research projects, you are trained by experts in the field.

One of the main research focuses of the Hortus botanicus Leiden is to study how the current biodiversity we see today, has originated, changed, and developed over time. The Hortus wants to study the relationship between species in specific focal taxa and see how they have diverged over time.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.