Inaugural lecture

The Faculty of Science is located at the Leiden Bio Science Park. It was founded more than two centuries ago and currently, more than 8000 people are working and studying at the eight institutes.

Hoe kijken Nederlandse bedrijven naar online prijsdiscriminatie? Kimia Heidary, Bart Custers, Helen Pluut en Jean-Pierre van der Rest schreven hier een artikel over.

When you apply for admission, you’ll be asked to submit several documents.

kiem grant: Investigating the anti-inflammatory potential of the PRG4 protein in preventing and alleviating rheumatoid arthritis

Getting personal

When you apply for admission, you’ll be asked to submit several documents.

When you apply for admission, you’ll be asked to submit several documents.

When you apply for admission, you’ll be asked to submit several documents.

When you apply for admission, you’ll be asked to submit several documents.

This one-year master's programme explores the political and cultural evolution of the world from a long-term, and broad comparative perspective. This creates a better understanding of the entangled nature of today's society.

History of Inequality and Power provides you with an in-depth understanding of the past and present that will contribute to solving current societal problems.

The one-year Master's specialisation in Ancient History: Empires, Societies and Cultures offers an attractive mix of theoretical knowledge and practical experience.

The starting point for this research project is the notion that the human brain is susceptible to all kinds of fallacies and biases that affect our perceptions and influence our reasoning outside of our conscious awareness. Indeed, most people think they are merely observing facts and that they process…

The center studies the many ways in which issues of law and justice are dealt with in art and literature with a focus on liminal issues and cases. These are issues and cases where law comes to the limits of what it is capable of dealing with and art and literature explore the implications of what is…

The Cryogenics Department has a liquid helium production unit and an automatic liquid nitrogen filling plant.

PURPOSE: To determine the effect of elasticity on the skin permeation of ketoprofen from surfactant-based vesicular formulations and elastic liposomes.

Because of their large surface area and immunological competence, mucosal tissues are attractive administration and target sites for vaccination.

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Dendritic cells (DC) play a prominent role in the priming of CD8(+) T cells. Vaccination is a promising treatment to boost tumor-specific CD8(+) T cells which is crucially dependent on adequate delivery of the vaccine to DC.

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotor: A.P. IJzerman

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

Promotores: J. Jonkers, K.E. de Visser

In light of climate change, it is crucial to determine whether plant species can adapt to future climates to avoid extinction. Plants adapt to various conditions by altering their functional traits, such as leaf size or photosynthetic rate. Some traits appear linked and vary together between species,…

Promotor: J. Kuiper

PhD candidates carry out a programme of independent research and additional limited) course work, culminating in production of a PhD thesis in typically 4 years.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Utilizing the polymeric platform of polypept(o)ides, this thesis describes synthesis and investigation of novel triblock copolymers to obtain carrier systems with multiple compartments for efficient siRNA delivery. Although the individual microstructure of nanoparticles differs depending on the polymeric…

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Promotor: Prof.dr. J. Kuiper

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

How are the epidermal lipid pathways involved in health and disease.

Source: J Med Chem (2015)

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen