We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

To what extent can digital technologies be considered as authorities?

The goal of the MODOMA-project is to create a computer model of language acquisition.

In this project, we aim to obtain a quantitative understanding of the role of the immune system in tumor regression, of the role of tumor cell heterogeneity in cancer growth and of tumor cell migration properties.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

In this project we study the properties of statistical- and rule-learning mechanisms in relation to the acquisition and evolution of language. We ask to what extent these mechanisms are unique to humans - or to human language - by comparing the acquisition of vocal structure in two species: humans (infants)…

Simulations of galaxies help researchers understand astronomical observations better. The EAGLE simulation, a large project in which Leiden astronomers play a leading role, shows the evolution of the Universe, from just after the Big Bang to the present day.

Promotor: Prof.dr. J.N. Kok

Promotores: Prof.dr. H. S. Overkleeft, Prof.dr. G. A. van der Marel

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

For a successful implementation of an educational reform, teachers need to regard the proposal as being practical. I used a modular, success-oriented approach to make a context-based reform practical for implemtentation in Duthc biology education. educational reform, modular, teachers, biology, success-oriented,…

Promotor: C.W.J. Beenakker, Co-Promotor: A.R. Akhmerov

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

Promotores: H.A. Udo De Haes, P.M. Brakefield

A P300-based Brain Computer Interface character speller, also known as P300 speller, has been an important communication pathway, under extensive research, for people who lose motor ability, such as patients with Amyotrophic Lateral Sclerosis or spinal-cord injury because a P300 speller allows human-beings…

Data analysis with Python and R are rapidly becoming essential skills for modern scientists. Therefore, we are offering courses to develop your scientific computing skills. Those courses are optional for LACDR PhD candidates.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Lecture

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Accelerating the diagnosis and personalising the management of inherited metabolic diseases.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

How does an embryonic stem cell decide if it becomes a heart cell or a kidney cell? That’s the question computational biologist Maria Mircea studied for her PhD research. She looked at the inside of individual cells to analyse how they change. This is what she discovered.

We review the state-of-the-art in the theory of dissociative chemisorption (DC) of small gas phase molecules on metal surfaces, which is important to modeling heterogeneous catalysis for practical reasons, and for achieving an understanding of the wealth of experimental information that exists for this…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Natural Computing is the field of research that investigates both human-designed computing inspired by nature and computing taking place in nature, i.e., it investigates models and computational techniques inspired by nature and also it investigates phenomena taking place in nature in terms of information…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Promotor: S.J. Edixhoven

As of 1 September, Jeroen van Zon started as professor by special appointment in Quantitative Developmental Biology at the Institute of Biology Leiden (IBL). Van Zon is also group leader of Quantitative Developmental Biology at the physics research institute AMOLF. Three questions about his new role…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Nonparametric Bayes for high-dimensional models: contraction, credible sets, computations

FAIRDOM consortium is an open initiative of various partners including funding programmes, large-consortia, institutes, small groups as well as individuals.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Can we use quantum computers in a way that is also relevant to society? With the help of a 2-million-euro NWA grant, Leiden University will work with partners such as Surf, Google and Volkswagen to demonstrate that quantum computers are also of value outside the lab.

The 18.8 million euro NWO Zwaartekracht grant for quantum software which Amsterdam, Delft and Leiden landed collectively, means for Leiden University among others the appointment of two new permanent scientific staff members, who will each form their own research group, divided among Computer Science,…

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

Brand-new professor Gerard van Westen works at the intersection of artificial intelligence and drug development. For the new chair in Artificial Intelligence and Medicinal Chemistry, he uses computer models to make drug development more efficient. Our ultimate goal is a virtual human which allows you…

Physicist Martin van Exter works with light at nanoscale, at the forefront of nanocomputer research. But as Director of Education he also has a vision for physics teaching. Inaugural lecture 18 November.

Source: Nat Biotechnol, Volume 32, Issue 12, pp. 1213-22 (2014)

Roel Wouters (24), a biology student at Leiden University, is a finalist in the election for UN youth delegate for Biodiversity and Food. The digital polls open for a week on Friday 22 October. Under-30s can vote for Roel at www.stemroel.nl.