Key publications of the Cancer Drug Target Discovery group

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

PhD defence

Smart algorithms and powerful processors are just as essential for astronomy as big telescopes. Astronomers at Leiden University therefore constantly operate at the interface between astronomy and data science.

To get a feeling of how we operate at LED3 when it comes to Early Drug Discovery, please browse through our case studies. When you select a case study you’ll find relevant contacts.

This thesis focuses on the study of transient and variable radio sources in the universe.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Promotor: Prof.dr. M. de Jong, Co-Promotor: Dr. A.J. Heijboer

So-called

The Centre for Digital Heritage undertakes collaborative international research in the field of Digital Heritage. It is an initiative of the University of York.

Leiden University began the construction of a new University Sports Centre in collaboration with the construction and design firm Binx Smartility. The current sports center no longer meets sustainability requirements and is also becoming too cramped. The building will also serve as an examination ce…

Playing the piano with your forearm, plucking the strings, sawing through the piano: pianist Luk Vaes's doctoral dissertation covers all the techniques of play for which a piano is NOT designed. His defence ceremony will consist of three concerts and a public defence. 'Musicians were using the interior…

Arts and leisure, Arts and leisure

In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.

This project employs a systematic experimental approach to examine the interaction of these two hitherto independent lines of research (tone sandhi and focus realization) in six dialects of Chinese, which lie on a continuum between dialects with dense tonal distributions and sparser distributions. In…

How does stress affect different components of behavioral impulsivity and aggression in patients with Borderline Personality Disorder compared to clinical controls (patients with Attention Deficit Hyperactivity Disorder) and healthy controls?

Can Zebra finches learn to distinguish two very similar Dutch words? Research by behavioral biologist Verena Ohms proved that they can identify 'wit' and 'wet'. Ohms published her findings in

We study cell-fate decision-making using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

In this 3-volume set of primary sources, Lionel Laborie and Ariel Hessayon bring together a wide range of vital sources for the study of prophecy in the early modern world. This meticulously edited collection includes rare material and fascinating manuscripts published in English for the first time.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

This article discusses the impact of symbolic gender representation on the willingness of citizens to coproduce.

This thesis focuses on two processes involved in fighting infections: metabolism and immune cell motility and navigation.

Schuurman examines how Russia is escalating its covert operations against European countries.

Humanities Campus Project is the name of the redevelopment of the Witte Singel-Doelen Complex, the location of the Faculty of Humanities and associated knowledge partners and institutes. Over a period of ten years the complex will undergo a gradual metamorphosis, while classes continue to be taught.…

Dynamic nuclear polarization with paramagnetic agents can enhance nuclear magnetic resonance signals by orders of magnitude. The mechanism of enhancement depends a.o. on the magnetic resonance properties of the agents used. Electron spin relaxation times at NMR relevant magnetic field/microwave frequencies,…

This dissertation derives from the development of tools for algorithmic composition which extract pitch materials from sound signals, analyzing them according to their timbral and harmonic properties, putting them into motion through diverse rhythmic and textural procedures.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

Promotor: Prof.dr. E.J.J. Groenen

The subject areas covered encompass functional genomics, signal transduction, cellular differentiation, development, host-microbe interactions and animal behaviour.

PhD defence

PhD defence

PhD defence

Electric noise can be useful for scientists but inconvenient for chip manufacturers. They do share a wish to predict the amount of noise. PhD student Sumit Tewari overturns a century-old law relating noise to current. He defends his thesis on March 27th.

Neural networks have a wide range of applications. In Leiden, psychologists use them to build robot brains, whereas archaeologists use them to hunt for prehistoric graves.

The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'

Leiden University neuropsychologists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

The Chemical Probe Facility is part of the Leiden Early Drug Discovery & Development (LED3) center. Activity-based protein profiling (ABPP) is one of the pillars of chemical biology. ABPP determines the activity of entire protein families in living cells and tissues under physiological conditions, such…

The methodology helping us to prepare for and shape preferred futures.

Leiden University social scientists have shown that customised intervention pays off. A new fundamental research-based approach in children who are in danger of going off the rails has delivered spectacular results.

Here I propose to study the relationship between autonomic pupil-synchronisation and trust, at the behavioural and neural level, and examine a targeted set of possible contextual moderators.

Parents may pass anxiety onto their offspring by exposing them to anxious behaviors in novel situations. Just as the parents’ anxious signals lead to anxiety, parents’ confident signals can ward off anxiety in the offspring. This project is seeking a new way to break anxiety transmission in the family…