What is the role of the rebound effect in achieving environmental savings from transport eco-innovation? Are traditional definitions of the rebound effect adequate in the context of transformative innovations and multidimensional environmental issues?

This editorial to RHCPP discusses how COVID-19 can be seen as a 'creeping crisis' according to the authors of its lead article (Boin et al, 2020) and how resilience may depend on the real heroes behind the scenes of response to disaster and adversity.

How can cardiovascular responses index challenge and threat motivational states? How do challenge and threat states shape, and are shaped by, social relations?

De positie van kunst en kunstenaars in de westerse samenleving

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

Nos complace anunciar que el X Congreso Internacional de la Asociación de Hispanistas del Benelux tendrá lugar en la Universidad de Leiden del 1 al 4 de noviembre de 2023.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Nos complace anunciar que el X Congreso Internacional de la Asociación de Hispanistas del Benelux tendrá lugar en la Universidad de Leiden, Países Bajos, del 1 al 4 de noviembre del 2023.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

Please find here the BA- and MA-Courses taught on the subject of language learning at Leiden University.

The genomic DNA of every organism is organized and compacted in order to fit inside the cell. This is achieved by the joint action of numerous architectural proteins that aid in folding the genome. Genome folding is tightly interconnected with transcription, with genes in certain regions being silenced,…

Naar aanleiding van het 900-jarig bestaan van de Norbertijnen is er vooreerst een grote tentoonstelling "Als de bliksem. 900 jaar Norbertijnen" van 4 mei tot en met 1 augustus in de abdij van Park in Leuven. Daarnaast biedt Jos Bielen, cantor van de abdij van Averbode, een boeiende tocht aan doorheen…

De menselijke geschiedenis strekt zich ver uit vóór de tijd waarin de mensen opschreven wat er zoal gebeurde.

What drives the behaviour of accountability forums?

Do objectively correct solutions to ethical dilemmas exist? Or is ethics always a matter of your opinion against my opinion? How do you know what to do? What kind of thing is ethics anyway? Can you be an expert in ethics?

“Het is niet genoeg dat Amerika aanwezig is in de ruimte. Amerika moet domineren”, zegt Donald Trump tijdens een bijeenkomst met de Nationale Ruimteraad. Zodoende wil hij naast de land-, zee-, en luchtmacht een nieuwe militaire kracht oprichten: de Space Force. Ruimterecht deskundige Tanja Masson denkt…

The effects of many treatments are determined, to a significant degree, by factors other than the medicine or treatment itself. For example, placebo effects can be equal to the effect size of for example antidepressants or painkillers. Contributing factors are the trust placed in the doctor, the expectation…

Can the conditioning paradigm be used for checkpoint inhibition cancer treatment?

Some children and adolescents find it hard to attend school because of anxiety and/or depression, a problem which is often referred to as school refusal. The main research question is how we can best help these young people reduce their emotional distress and increase their school attendance in order…

Supervisor: Gerard van Westen

Although rarely considered by the pharmaceutical industry or clinicians, 24-hour rhythms in physiology are a factor of potential influence on the pharmacokinetics and pharmacodynamics of drugs.

Are you looking for a research project?

Knowledge and culture subproject 2:

In our HANDS!Lab for Sign Languages and Deaf Studies, we run projects pertaining to sign language linguistics with a focus on Africa. In addition, we are running projects on sign language teaching, tactile signing, deaf people’s experiences with the legal system, and deaf history.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Peter Rodrigues, Professor of Immigration Law, has been appointed as a deputy member of the Netherlands Institute for Human Rights for a period of eighteen months.

What is the role of auxin in the initiation and process of somatic embryogenesis?

What are the most important perpetuating factors of chronic fatigue and chronic fatigue syndrome, and which interventions are effective in influencing these factors?

Lange tijd wisten we ons thuis in een wereld die we meenden te hebben. Het bestaan in deze vertrouwde wereld vormde onze existentie, die we op een eigenlijke wijze op ons namen. Thans is de wereld echter niet meer wat hij was, en zijn we ook zelf niet meer wie we waren. ‘De wereld is weg’, zo dichtte…

Overall dispersion in LCA as result of inherent uncertainties, spread and unrepresentativeness.

Marietje Beemsterboer defended her thesis on 12 June 2018 (in Dutch)

In this project, the hypothesis that language contact crucially impacts the development of spatial grammar and phonology is investigated.

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

The chairman of an allotment garden association in the Dutch town of Helmond has come under fire as its regulations contain a controversial rule that a maximum of five plots can be rented by one single nationality.

Exploring the synergy of light therapy and exposure psychotherapy to enhance PTSD treatment outcomes.

This pioneering project will answer this question by examining migrants through the eyes of the courts between 1600 and 1900. It aims to reveal patterns of continuity and change in: 1. Treatment of migrants by criminal courts; 2. Violence and conflicts between migrants and native born.

The Pharmacy research group focusses on the development of predictive models to improve clinical drug efficacy and safety. We work on clinical problems that require further mechanistic understanding and strive for ultimate benefit to patients.

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

Our mission is to bring together research and practice focused on the improvement of mental health and the enhancement of treatment / psychotherapy success. To reach this goal we focus on the following paths:

The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacometrics and systems pharmacology modeling combined with translational experimental models to develop personalized treatment strategies for antibiotics and to combat antimicrobial…

Which criteria do ED patients and therapists evaluate as most relevant for recovery? Do patients and therapists differ in their evaluations? Do eating disorder patients differ from a healthy control group in their scores on the Recovery Scale?

Optimization, mechanisms of action and predictors of the outcome of light therapy in depression: A multicenter randomized trial

Recent publications in the BLRN book series can be found below.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

The Division of Systems Pharmacology and Pharmacy (SPP) aims to develop precision medicine approaches to characterize and predict variation in treatment response and enhance translational drug development strategies.

The Horizon 2020 project Sybil-AA (Systems Biology of Alcohol Addiction) focuses on modeling and validating disease state networks in human and animal brains for understanding pathophysiology, predicting outcomes and improving therapy in alcohol addiction. Alcohol addiction, the most severe form of…