The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Spatial analysis on the basis of material culture has always been one of the major topics in archaeological research. Designating Place analyses the urban space of Roman Ostia and Pompeii in different ways, namely via geophysical analysis, spatial analysis, iconographic analysis and epigraphic analy…

Promotor: Prof.dr. G.R. de Snoo

Promotores: C. J. ten Cate; M. A. Ainslie. Co-promotor: W. Slabbekoorn

CurveBend project aims to study the restauration of biodiversity in livestock landscapes through collective action, practical solutions, and research on ecological knowledge co-creation.

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

In this opinion article published in World Development, the authors present five research and policy priorities. While it is clear that ‘pluriversal’ designs need to guide the way forward (Kothari et al 2019), defining a set of key pillars can provide direction and purpose across this pluriversality.…

Ethiopian wolves are endangered diurnal Afroalpine rodent hunters. I investigated the interaction between wolves, rodents and human land use in Borena Sayint National Park (BSNP), Abune Yosef and Aboi Gara in Ethiopia.

Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

On February 7th, Lotte Dros-Hendriks succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Lotte on this great result.

In 'Dutch Atlantic Connections, 1680-1800', Gert Oostindie and Jessica V. Roitman, both of the Royal Netherlands Institute of Southeast Asian and Caribbean Studies (KITLV) and also affiliated with the History Institute of Leiden University, assemble an internationally acclaimed selection of authors,…

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

The narrow but long stretched stript of Frisian land along the North Sea was already occupied before Roman times. However, man repeatedly suffered setbacks when he tried to extend his living space, both in the tidal marshes and the peat area south of them.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Gaucher disease is a rare metabolic disorder, in which a mutation of the enzyme glucocerebrosidase (GBA1) causes buildup of its substrate glucosylceramide and the deacylated counterpart glucosylsphingosine in lysosomes.

Una investigación definitiva sobre el nacionalismo que disecciona los patrones y las dinámicas que lo han convertido en un fenómeno mundial en auge.

Animal Sciences’ contributions to the Biodiversity & Evolution research theme include evo-devo research, the evolution of cognitive and behavioural traits, and the evolutionary mechanisms of stress adaptation. This research involves both indoor and outdoor studies.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Let’s get this out of the way: Hillary Clinton won the 26 September 2016 presidential candidates television debate. Handily.

Lecture, Book Presentation

What workflow of non-destructive techniques provides accurate, valuable data to improve our understanding of Caribbean archaeological landscapes? How were Amerindian settlements configured?

Rembrandt experts have been puzzling over this painting from 1626 for years. The work may have been commissioned by someone from University circles and may depict a judgment. It can be seen at Gravensteen, a building that served as a prison between 1463 and 1955. This historical building later became…

Education and Organisation Development

Superconducting devices such as SQUIDS (Superconducting Quantum Interferometry Device) can perform ultra-sensitive measurements of magnetic fields. Leiden physicsts invented a method to 3D-print these and other superconducting devices in minutes.

NWO has granted Jan Aarts en Vadim Cheianov a Physics Projectruimte, a granting instrument for small-scale projects that propose innovative fundamental physics research that has a scientific, industrial or social urgency.

An overview of our exhibition catalogues and research monographs on the Middle Eastern collections.

Leiden University regularly confers honorary doctorates, and presents awards and prizes.

This research project from Leiden University looks at the opportunities and threats that flow from the existence of institutional and normative diversity in the area of fundamental rights for the effective protection of those rights in a pluralist world.

Joost Grootens contributes the introductory essay ‘Charles Joseph Minard: Critical Practice’ to the book ‘Le Système Minard’ on the French pioneer in the representation of statistical data in the 19th century.

In the field of Western art music, improvisation has become a much discussed topic. In this interdisciplinary study I argue that in this context, improvisation is not to be seen as a quasi-autonomous skill or art form, but as an aspect of music-making in general.

The Laboratory for Human Osteoarchaeology specialises in the macroscopic and microscopic analysis of human remains. We use cutting edge scientific approaches to address archaeological, historical, and anthropological research questions. In addition to paleopathological, histological, and 3D scanning…

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Enduring influence of Roman law

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

The experimental approach of science applied to artistic research

Proceedings of the XVII UISPP World Congress (1–7 September, Burgos, Spain). Volume 7/Sessions A4b and A12

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.