This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

In this opinion article published in World Development, the authors present five research and policy priorities. While it is clear that ‘pluriversal’ designs need to guide the way forward (Kothari et al 2019), defining a set of key pillars can provide direction and purpose across this pluriversality.…

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Una investigación definitiva sobre el nacionalismo que disecciona los patrones y las dinámicas que lo han convertido en un fenómeno mundial en auge.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

The effects of anthropogenic noise on interactions between predators and their prey are still little understood.

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Since my master's thesis on the landed property of the Frisian monasteries in the Middle Ages I am highly interested in the do ut des-aspects of the relation between religious houses and the lay world. Key words here are: property, power, patronage and the role of religious institutions in the 'salvation…

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

Promotor: C.J. ten Cate, Co-promotor: H.W. Slabbekoorn

Does Artifical Light at Night (ALAN) disrupt seasonal physiological and behavioral patterns in migrating freshwater fish?

Spatial analysis on the basis of material culture has always been one of the major topics in archaeological research. Designating Place analyses the urban space of Roman Ostia and Pompeii in different ways, namely via geophysical analysis, spatial analysis, iconographic analysis and epigraphic analy…

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

In 'Dutch Atlantic Connections, 1680-1800', Gert Oostindie and Jessica V. Roitman, both of the Royal Netherlands Institute of Southeast Asian and Caribbean Studies (KITLV) and also affiliated with the History Institute of Leiden University, assemble an internationally acclaimed selection of authors,…

The name ‘Jambi flora’ refers to fossil plants found as part of a rock formation from the Early Permian (296 million years old), located in the Jambi Province of Sumatra, Indonesia.

Hermeneutics and the Humanities: Dialogues with Hans-Georg Gadamer / Hermeneutik und die Geisteswissenschaften: Im Dialog mit Hans-Georg Gadamer

Promotor: Prof.dr. G.R. de Snoo

CurveBend project aims to study the restauration of biodiversity in livestock landscapes through collective action, practical solutions, and research on ecological knowledge co-creation.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

On February 7th, Lotte Dros-Hendriks succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Lotte on this great result.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh

Engineering an efficient microbial enzymatic polyethylene degradation pathway via an innovative combination of biochemistry and computational biology tools for enzyme discovery and characterization.

Superconducting devices such as SQUIDS (Superconducting Quantum Interferometry Device) can perform ultra-sensitive measurements of magnetic fields. Leiden physicsts invented a method to 3D-print these and other superconducting devices in minutes.

NWO has granted Jan Aarts en Vadim Cheianov a Physics Projectruimte, a granting instrument for small-scale projects that propose innovative fundamental physics research that has a scientific, industrial or social urgency.

Lecture, Book Presentation

Education and Organisation Development

What workflow of non-destructive techniques provides accurate, valuable data to improve our understanding of Caribbean archaeological landscapes? How were Amerindian settlements configured?

Rembrandt experts have been puzzling over this painting from 1626 for years. The work may have been commissioned by someone from University circles and may depict a judgment. It can be seen at Gravensteen, a building that served as a prison between 1463 and 1955. This historical building later became…

Let’s get this out of the way: Hillary Clinton won the 26 September 2016 presidential candidates television debate. Handily.

Leiden University regularly confers honorary doctorates, and presents awards and prizes.

An overview of our exhibition catalogues and research monographs on the Middle Eastern collections.

This research project from Leiden University looks at the opportunities and threats that flow from the existence of institutional and normative diversity in the area of fundamental rights for the effective protection of those rights in a pluralist world.

To date it has proved very difficult to convert the promises of the miracle material graphene into practical applications. Amedeo Bellunato, PhD candidate at the Leiden Institute of Chemistry, has developed a method of cutting graphene into smaller fragments using a diamond knife. He can then construct…

S.S. Kolipaka’s thesis questions and investigates the survival prospects of reintroduced tigers and their offspring’s in the human dominated landscape of Panna tiger reserve in India.

Promotor: J.G.E.M.Fraaije, Co-promotor: A. Kros

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

The making of sacrifices seems part and parcel of any elite sportsperson’s life. Remarkably, the insights that we find in the current literature in social sport studies are not able to make sense of the references to sacrifice in the data that emerged in the context of this study on the social significance…

The company Azafaros was established in 2018 to translate innovative science from Leiden University and Amsterdam University Medical Center into novel disease-modifying treatment modalities for rare genetic metabolic disorders such as lysosomal storage diseases.

The experimental approach of science applied to artistic research

Proceedings of the XVII UISPP World Congress (1–7 September, Burgos, Spain). Volume 7/Sessions A4b and A12

Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters

Enduring influence of Roman law

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh