Within this thesis the central stage is taken by the discovery and investigation of transglycosylation of sterols. First, investigation focuses on the development of a method to accurately detect and quantify glucosylated metabolites in biological materials.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

In this dissertation, we study partition-based models that can be used both for interpretable predictive modeling and for understanding data via interpretable patterns.

How can a CLIL approach, with a focus on disciplinary literacies, improve the teaching of the LLA programme’s literary component in senior TTO?

Demonstration experiments are a potentially powerful instrument to improve the micro-macro thinking of students in secondary education. Therefore we want to design a practical and generative approach to assist teachers to develop lessons with a demonstration experiment.

As a PhD candidate you will need a set of different skills in order to successfully complete your PhD and to get ready for your next step in your career. Therefore, Leiden University has set up a PhD Training Programme that supports you in this process.

The overall aim of the project is to investigate effective ways to strengthen vocational identity of at-risk adolescents in order to contribute to a successful transition from late secondary to post secondary lower vocational education or to work.

Higher design and engineering educators have different views on what a new or renewed curriculum should entail, content-wise as well as pedagogically. This research aims to describe how these ‘curriculum perspective perceptions’ influence working definitions, end goal formulation, and the scope of results…

When you have finished your dissertation, it is time to prepare for the defence procedure.

How is the instructional practice of teachers connected to the mastery of reading skills of students in kindergarten (group 2) to the third grade (group 5) of primary education in Curaçao?

During your PhD, you make agreements with your supervisors concerning your personal development and the supervision you receive. No later than three months after the start of your appointment, these agreements should be recorded in a Training and Supervision Plan (TSP). External PhD candidates must…

The Leiden Science Young Talent Award is awarded yearly to a student who completed their bachelor’s degree with an excellent thesis.

Unraveling culturally responsive attitudes, noticing skills, knowledge and reasoned practices of expert teachers.

How can reciprocal learning of mentor and mentee about PCK (Pedagogical Content Knowledge) during the secondary school internship be established?

What is effective viewing behavior for foreign language learners and how can teachers effectively train language learners to apply effective viewing strategies that will maximize their learning when viewing subtitled materials?

How do university lecturers perceive and exercise teacher agency, and what approaches can effectively explore agentic actions and underlying beliefs?

The Animal Welfare Body Leiden (AWB) is an internal entity responsible for the well-being of all laboratory animals at Leiden University and the Leiden University Medical Center. It is actively involved in all aspects of research involving animals. The AWB has several legal responsibilities, including…

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

PhD defence

Renate Dekker defended her thesis on 7 November 2017.

This critical edition covers the first two parts of De secundis intentionibus by Hervaeus Natalis (14th century).

This thesis probes under what conditions quantum computing presents an advantage over classical computing.

PhD defence

We show that Kirchhoff ’s law of conservation holds for non-commutative graph flows if and only if the graph is planar. We generalize the theory of (Euclidean) lattices to infinite dimension and consider the ring of algebraic integers as such a lattice.

In this thesis we use Josephson and noise scanning tunneling microscopy for the study of conventional, unconventional (iron-based) and disordered superconductors. On the one hand, Josephson scanning tunneling microscopy allows us to directly visualize the superfluid density with high spatial resolut…

The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.

Single-Molecule Microscopy (SMM) techniques constitute a group of powerful imaging tools that enable researchers to study the dynamic behavior of individual molecules.

PhD defence

PhD defence

In this thesis I describe the results of Pulsed Interleaved Excitation and Fluorescence (Cross) Correlation Spectroscopy (PIE-F(C)CS) combined with single-pair Förster Resonance Energy Transfer (spFRET) used to study dynamics in single nucleosomes, which depends on subtle differences in the length of…

PhD defence

The formation of stars and planets happens over multiple scales, which can interact. In particular, planet formation happens in the dense, complex environment of star forming regions.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

Traditional hypothesis testing requires researchers to set a fixed sample size in advance. After collecting data, the test determines whether to reject the null hypothesis.

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

Integrins play an essential role in multicellular life by connecting cells to the extracellular matrix.

The outbreaks of AIDS and COVID-19 showed clearly how infectious viruses can influence people’s lives. Investigating the changes in the host metabolism may provide a paradigm shift to consider immune-metabolic interactions as therapeutic targets.

Edegar da Conceição Savio defended his thesis on 28 January 2016

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

PhD defence

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

This thesis examines silicon pore optics (SPO), a technology that exploits silicon wafers from the semiconductor industry to create extremely high quality X-ray optics, by studying its manufacturing process, applications, and prospects.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.