Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Evolution is all around you every day. This is the message of a Massive Open Online Course (MOOC) of Leiden University and Naturalis that is offered free of charge to anyone interested.

Key publications of the Computational Drug Discovery group

To explore the potential of marine microorganisms as producers of novel antimicrobial agents and as bioprotectants in aqua- and agriculture, using an integrative, ecology-based strategy for bioprospecting.

This thesis investigates the application of deep learning techniques in image analysis across various domains, focusing on four main themes: feature extraction, classification, segmentation, and integration, demonstrating the transformative potential of these technologies.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

A complex community of microbes develops in the infant gut shortly after birth. We call this community the infant gut microbiota. The microbiota influences the health of the infant, which makes the composition and function of the infant gut microbiota an important topic to study.

The Science faculties of Universitas Indonesia (UI) and the Universiteit Leiden signed agreements on Tuesday April 12 that will strengthen cooperation between the Faculties. The agreements were signed at the closing of a two day visit of a delegation from Indonesia. The delegation, which was led by…

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

This thesis is about augmented reality (AR). AR is commonly considered a technology that integrates virtual images into a user’s view of the real world.

Promotor: Prof.dr. E. Deprettere

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

‘Make more room for nature on farmland and you'll be surprised at the result.' This was the advice from Geert de Snoo in his Dies lecture.

Short description about 20th anniversary of CEDC, the fieldstation in Cameroon, and 20 years of cooperation between Leiden University with the University of Dschang in Cameroon.

The first larger quantum computers will soon be available. These computers need new software. Researchers at Leiden University have been awarded a Gravitation grant to develop the necessary software. They will be collaborating with colleagues from other research institutions.

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

Simon Portegies Zwart, professor of Computational Astrophysics, uses computers to simulate the evolution of stars. We speak with him about his field and about the challenges of working with huge amounts of complex data.

How do public organizations use strategic regulatory communication in regulatory governance?

An assessment approach that tailors to children’s instructional needs

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Merijn de Bakker and colleagues of the IBL-research group of Prof. Mike Richardson provide a unique view on digit evolution in crocodiles and birds in their recent study published in Nature.

Marie-Jeanne Holveck and Katharina Riebel from Behavioural Biology at the Institute of Biology at the Faculty of Science published their research in Proceedings B of The Royal Society.

Physics professor Jan Aarts starts a collaboration with chip manufacturer Intel to perform fundamental research in low-power, cryogenic computing.

Three researchers from Leiden University have received awards in the Quantum Technology programme within the National Growth Fund, organised by NWO in collaboration with Quantum Delta NL. Read more about these three futuristic projects.

Natural history collections provide invaluable sources for researchers with different disciplinary backgrounds, aspiring to study the geographical distribution of flora and fauna across the globe as well as other evolutionary processes.