PhD defence

When a bacterium becomes more resistant to one antibiotic, it sometimes becomes more sensitive to another. To better understand this interaction, researchers from the Leiden Institute of Biology (IBL) and the Leiden Academic Center for Drug Research (LACDR) under supervision of Daniel Rozen and Coen…

Last Friday the global Antibiotics Awareness Week begun: an entire week dedicated to antibiotic use. Antibiotics researchers from the LACDR therefore set out to tell primary school pupils about their research. Through role-playing, pupils were drawn into the world of antibiotics: 'Can the teacher not…

More than 1.3 million people worldwide die of tuberculosis (TB) each year, making research on its prevention and control essential. Researchers from various disciplines in Leiden are studying TB. A symposium on 24 March will highlight different activities in the hope of boosting nationwide collabora…

Microscopic swimmers such as bacteria do not always swim alone. There are advantages to exchanging information and cooperating. Stefania Ketzetzi and colleagues now show in Nature Communications that human-made microswimmers, too, can cooperate.

A bacterium hiding from the immune system and picking up bits of DNA from its environment. The result: gaining new traits, such as better protection against antibiotics. Fortunately, we have not found such a damning scenario yet. However, PhD student Renée Kapteijn did find the first clues, which…

Leiden PhD candidate Jo-Anne Verschoor discovered that nearly twenty percent of the bacterial strains she studied could degrade plastic, though they needed some encouragement to do so. ‘Bacteria are just like people,’ says Verschoor. Her research was published in the journal Communications Biology,…

‘What I find most alluring about soil life is that you can steer it,’ researcher Martijn Bezemer of the Institute Biology Leiden (IBL) reveals. ‘You can ask: What do you want? And then I can transform the soil into something you need. At least, that is what we thought.’

Research to experiment with bacteria that grow like plants has been granted the NWO XS grant. These bacteria use light and carbon dioxide to grow, and will be designed especially for use in the biotechnological field. Tijn Delzenne and his supervisor Dennis Claessen can spend 50.000 euros on the exp…

Soil that is too wet, or too dry. Or with a lot or few nutrients. Due to climate change, the differences are becoming bigger, and plants must increasingly be able to adapt to survive. How do you make plants more stress-resistant? For this purpose, researchers from Leiden, along with other universities,…

For the first time, it was shown in living cells how the bacterium E. coli regulates genes that help it survive in a new environment. Biochemist Fatema Zahra Rashid managed to do this using a technique she fine-tuned. Her research into changes in 3-dimensional chromosome structure offers clues for ways…

Some bacteria, it turns out, have proteins much like ours that organise the DNA in their cells. They just do it a bit differently. This is revealed by new research from biochemists at the Leiden Institute of Chemistry and the Max Planck Institute for Biology. The discovery helps us better understand…

Bacteria temporarily live without their cell wall if dangerous viruses are near. A remarkable feature, as the cell wall is a sturdy barrier against threats. Still, the discovery has a logical explanation ánd might be of a consequence for fighting pathogenic bacteria, according to Véronique Ongenae,…

Current antibiotics only address very few target proteins in bacteria to kill them. Researchers know that there are more possible target proteins to tackle the bacteria. The question is: which ones. Thanks to the NWO Vidi Grant, Assistant Professor Molecular Physiology Stephan Hacker and his team can…

A patent for what may be a potent, new antibiotic. And: a clear overview of promising approaches to overcome a crucial resistance tactic employed by bacteria. In the span of one week, two researchers from Leiden are receiving their PhDs, each of them on an important step in the battle against bacteria…

From 22 to 24 October, researchers of the MARBLES-project informed museum visitors about microbes: bacteria and fungi that live all around us. The event was organised around the Micro-day of Leiden, which is this year’s EU City of Science.

Transferring poo from healthy donors to the intestines of chronically ill people has beneficial effects on these recipients’ gut bacteria, also in the longer term. This is the conclusion of research by the Leiden University Medical Center (LUMC) and the Netherlands Donor Feces Bank (NDFB).

Collaborating and learning from other fields – that is what bioinformatician Hannah Augustijn enjoys most about doing research. During her PhD at Leiden University, she developed new ways to search within bacteria for the antibiotics of the future.

Two research groups involving Leiden University have been awarded a major European grant, the ERC Synergy Grant. This for research on the development of membranes that can clean water and purify medical drugs and research on the biological clock in certain bacteria.

A microscope with incredible sharpness that leaves samples unharmed – Guido Stam helped develop one. During his PhD research, he combined light and electrons to study biological samples. ‘We can now measure things that simply weren’t possible before.’

‘Working in Leiden is a dream come true.’ Ákos Kovács studied in his birth country Hungary and worked in Germany, Denmark and Groningen. As professor of Microbiome Ecology at IBL, he immediately started working together with his new colleagues to make discoveries about the versatile bacterial species…

Phage therapy is a novel yet unmatured therapeutic approach in the face of the crisis of antimicrobial resistance (AMR). Dr. Tingjie Guo received a grant from the Elise Mathilde Fund and the LUF to develop innovative phage-antibiotic combination treatment strategy for combating AMR.

Whether a microbe is beneficial or harmful to a plant can now be predicted with high accuracy thanks to bacLIFE. This bioinformatic tool with an intuitive interface makes it much easier to unlock the secrets of bacterial genomes. A group of Leiden biologists presented it in Nature Communications.

Bacteria carry countless hidden treasures in their DNA: fragments that could hold the key to new medicines. But how do you pick out the most promising ones from millions of options? ‘Look at the switches that turn genes on and off,’ says molecular biologist Gilles van Wezel.

Two consortia led by Leiden researchers have been awarded over one million euros by the Dutch Research Council and the Ministry of Health, Welfare and Sport to find solutions to antimicrobial resistance.

PhD defence

Defending your PhD research in front of nearly 300 elementary school students: that was the challenge faced by PhD candidates Jo-Anne Verschoor and Marinka de Willigen during the VUURVLIEGEN competition organised by the Centrum JongerenCommunicatie Chemie (C3). After an exciting competition, the children…

PhD defence

Regardless of whether you work at a desk or in a lab, all workplaces have their risks. As your employer, the University aims to create a healthy workplace and to limit possible health risks. Here you will find the main risks and measures that we take to reduce them.

Regardless of whether you work at a desk or in a lab, all workplaces have their risks. As your employer, the University aims to create a healthy workplace and to limit possible health risks. Here you will find the main risks and measures that we take to reduce them.

Soil ecologists Emilia Hannula (Leiden) and Elly Morriën (UvA) received the Golden Medal of Teylers Tweede Genootschap on 5 November. They received the prize for their submission to a competition on sustainable soil management.

It has only recently been discovered that single-celled organisms (bacteria and archaea) also have histones—proteins that structure DNA. Now, Leiden PhD candidate Samuel Schwab has found that the histones in these organisms are much more diverse than previously thought. Schwab and his colleagues describe…

Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…

A group of biology students are working on a solution to the world’s plastics problem by getting bacteria to make biodegradable plastic.

Biological agents are micro-organisms such as bacteria, parasites, moulds, viruses and their waste products. This category also includes genetically modified variants (GMOs). These agents may form a risk for your health, which is why we apply a number of legal and other guidelines to prevent people…

Tuberculosis bacteria survive by hiding in our immune cells. In her PhD research, biologist Salomé Muñoz Sánchez explores how boosting the body’s own defenses might outsmart this deadly pathogen. Her work reveals two key proteins that help immune cells destroy the bacteria.

Leiden researchers have discovered an enzyme that helps bacteria feed on everyday plastics. This common enzyme could play a crucial role in future research and eventually in addressing the global plastic crisis. The study was published in Nature Communications.

What started as an idea during a social gathering led to an unexpected breakthrough in research on resistant bacteria. Biologists and chemists from Leiden developed a new substance that proves to be effective against bacteria resistant to antibiotics. They published their discovery in Nature Chemist…

In a world where bacteria are increasingly resistant to antibiotics, Emma van Groesen set out to find a solution. This month she obtained her PhD, after four years of research into new variants of the antibiotic vancomycin. With success.

David Versluis successfully simulated an infant gut virtually. This is crucial for research on improvements in formula milk. Currently, such research primarily relies on diaper contents, which is not optimal. Versluis defended his doctoral thesis on April 23.

The antibiotic EVG7, developed in Leiden, has proven capable of fighting the dangerous gut bacterium C. difficile with only a minimal dose. What’s more, the bacterium is far less likely to return, a major issue with existing antibiotics. The research was published in Nature Communications.

Optimised antibiotic combinations can combat bacteria more effectively while also slowing the development of resistance. Scientists from five European countries are joining forces to identify such combinations and provide tools for others to do the same. The project is led by Professor Coen van Hasselt…

Antibiotic resistance is an economic problem. Pharmaceutical companies cannot earn much from antibiotic research, so they do not invest in it. This makes it important that universities do so, says Ned Buijs.

Resistance to antibiotics is a major problem in health care. Thanks to a grant from the Elise Mathilde Fund and the LUF, pharmacologist dr. Coen van Hasselt can look for new dosing schedules to reduce the development of antibiotic resistance.

Nathaniel Martin, Professor of Biological chemistry, wondered what would happen if you take an antibiotic that has been known for 70 years and try to improve it with the latest tools of modern chemistry. Turns out it can become up to a hundred times more potent and prevent the growth of some drug-resistant…

Researchers need to work in specialized environments when they work with dangerous bacteria and viruses. These microbes spread easily, so only in labs with a high biosafety levels they can be studied. Unfortunately, to look at the microbes properly, expensive microscopes are needed that are not always…

Multidrug-resistant pathogens and worldwide pandemics are increasing, making infectious diseases more prevalent. To develop new treatments, deeper knowledge of the interaction between bacteria and human cells is required. Ariane Briegel recently became a Medical Delta professor and studies such path…

Mimicking photosynthesis to produce bioplastics sustainably and efficiently. Researchers from the Institute of Biology Leiden (IBL) and the Leiden Institute of Chemistry (LIC) will assess this new approach. ‘An exciting opportunity to explore a new, appealing research topic in a collaboration between…