The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

How presence, abundance and enzymatic activities of AM and EM fungi differently affect soil carbon sequestration processes?

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In this opinion article published in World Development, the authors present five research and policy priorities. While it is clear that ‘pluriversal’ designs need to guide the way forward (Kothari et al 2019), defining a set of key pillars can provide direction and purpose across this pluriversality.…

PhD defence

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Exploring the mechanism of targeted nanoparticle-mediated drug delivery using the zebrafish model

Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…

Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

He presented his PhD research entitled “Kick-starting drug development; translational systems pharmacology using innovative zebrafish experiments and advanced computational modelling”. During his presentation, Rob highlighted the advancements he made in using zebrafish as model in system pharmacolog…

The Leiden University-European Center for Chinese Medicine and Natural Compounds (LUECCM) is a virtual research Centre bringing together research projects of many different researchers from different origin.

Pharmacologist Amanda Foks is one of the ten talented scientists who received a Dekker grant from the Hartstichting. She receives €427,000 to find a way to rejuvenate immune cells to prevent infarcts. Foks was nominated as Discoverer of the Year in 2016.

Mathematical and computational analysis of the dynamics of polar transport of the plant hormone auxin.

The right medicine in the right dosage for every patient, that is something medical science aspires. 'Personalised medicine' is the term for that. But it does require a lot of research with patient data and that can be hard to get due to privacy legislation. Researchers Laura Zwep and Coen van Hasselt…

This is an Erasmus+ International Credit Mobility project of Leiden University Medical Center with Boston Children’s Hospital in the USA.

Within the Chinese medicine, more than 80% of the constituents of the preparations are derived from plants. Like any other organism, plants are constantly interacting with their changing and often harsh environment during the various phases of their life cycle.

How to identify patients at risk of developing devastating, metastatic disease and facilitate the development of personalised treatment for prostate cancer patients?

Chair of LU-European Center for Chinese Medicine and Natural Compounds, Institute of Biology, Leiden University - the Netherlands

Education in (Chinese) Medicinal Plants associated to the Hortus botanicus in Leiden - Which Traditional Chinese Medicinal plants can be grown in the Hortus? - Establishing of a database which Chinese medical plants are available in Dutch Botanical Gardens - Data validation (correct identification,…

Promotor: Prof.dr. R. Verpoorte, , Co-Promotor: Young Hae Choi

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Blood, Sweat and Tears: The Changing Concepts of Physiology from Antiquity into Early Modern Europe

In 2021 many of our students and staff won fantastic prizes and were awarded important research grants. This is our traditional review of these successes as the end of one year marks the beginning of another.

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At the Leiden University Medical Centre (LUMC), you will be prepared for the world of tomorrow. We bring research and patient care together in a unique way in our education.

Are you considering starting with the Master's Transfusion Medicine and Cellular and Tissue Therapies? Please feel free to contact us if you have any questions.

In this project we ask: how does pollution manifest as part of different practices, both socially and materially.

Doctors and pharmacists should take greater account of obesity when dosing medicines. The distribution in the body and the breakdown of a medicine can vary considerably in obese patients. This is stated by clinical pharmacologist Catherijne Knibbe in the Annual Review of Pharmacology and Toxicology.

A tried and tested medication for treating ADHD works differently than expected in the brains of healthy individuals during rest: rather than stimulating brain activity, it suppresses it.

In 2022, many of our staff and students won fantastic prizes and were awarded important research grants.

Leiden University researchers and their collaborators report the development of new research frameworks that use day-to-day smartphone behavior gathered from a large sample of healthy people to help understand aging, and how aging alters with epilepsy and stroke. These reports occupy two back-to-back…

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

We aim to conduct as few animal experiments as possible. We are continually exploring methods to Replace, Reduce, and Refine animal experiments, commonly referred to as the three Rs. Additionally, we assess each study to ensure the implementation of the 3Rs has been maximised. The Animal Welfare Body…

Here you can find an overview of the Erasmus+ projects undertaken by Leiden University since 2015.

Division contact information & address

PhD defence

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

PhD defence

This is an Erasmus+ International Credit Mobility project of Leiden University’s Faculty of Medicine with University of Indonesia, Faculty of Medicine, and Universitas Katolik Indonesia Atma Jaya in Indonesia.

This Master enables you to practice professional activities such as: lead research projects and develop technically qualified projects in the field of transfusion medicine.

In 2023, many of our students and staff won great prizes and secured important research grants.

Improving healthcare with our scientific discoveries: that is the goal of pharmaceutical research at Leiden University. And there’s a lot involved in that. Our research starts with the discovery of the effect achieved by a particular substance, and sometimes continues all the way through to the development…

Our research programme collaborates with all kinds of partners to achieve our goal: bringing scientific discoveries to the clinic as soon as possible.